Study of Physicochemical Characteristics of Drug Substances

Study of physicochemical characteristics of drug substances

Understanding the Physicochemical Characteristics of Drug substances is paramount in pre-formulation studies. These characteristics influence the drug’s behavior during formulation, processing, and storage, as well as its bioavailability and therapeutic performance. Key Physicochemical Characteristics: Physical Properties: Physical form (crystalline vs. amorphous) Particle size and shape Flow properties Chemical Properties: Solubility and dissolution rate pKa (acid … Read more

Goals and Objectives of Pre-formulation Studies

goals and objective of pre formulation

The primary goals of pre-formulation studies are: Understand the Drug’s Characteristics: To determine the physical and chemical properties of the drug substance. To understand how these properties influence the drug’s performance, stability, and compatibility. Support Formulation Development: To guide the selection of excipients, processes, and packaging materials for dosage form development. To identify and mitigate … Read more

Energy-rich compounds

Energy-rich compounds are essential for cellular metabolism, acting as molecular energy stores and carriers. These compounds release significant energy upon breaking high-energy bonds, driving various biological processes. Key Energy-Rich Compounds Adenosine Triphosphate (ATP) Structure: Adenine base, ribose sugar, and three phosphate groups. Function: Primary cellular energy currency, providing energy for muscle contraction, active transport, and … Read more

Redox potential

Redox potential

Redox potential (Eh) is a measure of a chemical species’ tendency to gain (reduction) or lose (oxidation) electrons, crucial in biochemical energy transfer and electron transport processes. Basics of Redox Potential Definition: Indicates a molecule’s ability to accept (oxidizing agent) or donate (reducing agent) electrons. Expression: Measured in volts (V) or millivolts (mV) relative to … Read more

Relationship between free energy, enthalpy, and entropy

Relationship between free energy

The relationship between free energy (G), enthalpy (H), and entropy (S) is fundamental in biochemistry, determining the spontaneity and direction of chemical reactions in biological systems. These relationship between free energy (G), enthalpy (H), and entropy (S)thermodynamic parameters are interconnected through the Gibbs free energy equation, which predicts reaction feasibility. Gibbs Free Energy Equation The relationship … Read more

Exergonic and Endergonic Reactions

Exergonic and Endergonic Reactions

Exergonic and endergonic reactions are two types of chemical processes classified by their energy changes. An exergonic reaction releases free energy to the surroundings, resulting in a negative ΔG (ΔG < 0). An endergonic reaction requires an input of free energy from the surroundings, resulting in a positive ΔG (ΔG > 0). 1. Exergonic Reactions … Read more

Free Energy Concept

Free Energy Concept

In bioenergetics, free energy refers to the portion of a system’s energy that is available to do work. The specific form of energy used to understand biological reactions is called Gibbs Energy (G). It helps predict whether a chemical reaction will occur spontaneously under constant temperature and pressure. Gibbs Energy (G) is defined by the … Read more

Bioenergetics Introduction

Bioenergetics Introduction

Bioenergetics Introduction Bioenergetics Introduction: It is a critical subfield of biochemistry that focuses on understanding how living organisms acquire, transform, and use energy to sustain life. This complex process involves various biochemical reactions and pathways that convert energy from one form to another, enabling cells to perform essential functions such as growth, repair, movement, and … Read more

Protein

Protein

Protein are large, complex biomolecules essential for the structure, function, and regulation of cells, tissues, and organs. Composed of amino acid chains, their sequence determines their 3D structure and specific function. Proteins participate in metabolism, structural support, transport, signaling, and immune defense. Classification of Protein Proteins can be classified based on structure or function, reflecting … Read more

Introduction to Pre-formulation studies

Pre-formulation Studies

Pre formulation studies involve the investigation of physical and chemical properties of a drug to develop safe, effective, and stable dosage. Definition of Pre formulation studies: Pre-formulation is the initial phase in the drug development process that involves the comprehensive characterization of a drug substance’s physical and chemical properties. This stage precedes formulation development and … Read more