Study of Physicochemical Characteristics of Drug Substances
Understanding the Physicochemical Characteristics of Drug substances is paramount in pre-formulation studies. These characteristics influence the drug’s behavior during formulation, processing, and storage, as well as its bioavailability and therapeutic performance. Key Physicochemical Characteristics: Physical Properties: Physical form (crystalline vs. amorphous) Particle size and shape Flow properties Chemical Properties: Solubility and dissolution rate pKa (acid … Read more