B Pharmacy

Buffer Capacity

Definition of Buffer Capacity

  • Buffer Capacity (β): A quantitative measure of a buffer’s ability to resist pH changes.
  • Mathematical Expression:
  • $\beta = \frac{\Delta B}{\Delta{pH}}$
  • $\Delta \mathrm{pH}$
    = amount (in moles per liter) of strong acid or base added.
  • $\Delta B$
    = change in pH resulting from the addition.

Factors Affecting Buffer Capacities

  • Concentration of Buffer Components: Higher concentrations provide greater capacities.
  • Ratio of Acid to Base: Maximum capacity occurs when
  • Total Buffer Concentration: The sum of the concentrations of the weak acid and its conjugate base.

Importance

  • Stability: Ensures the pH remains within a narrow range during chemical reactions or storage.
  • Biological Systems: Maintains physiological pH crucial for life processes.

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