Butamben

Butamben is an ester-type local anesthetic used topically for pain relief by blocking nerve signal transmission.

Structure of Butamben

• It is an amino benzoic acid derivative with a butyl ester group attached to the benzene ring, providing enhanced anesthetic properties.
• Chemical Formula: C₁₀H₁₉NO₂

Mode of Action

• Sodium Channel Blockade: Blocks nerve impulse transmission by inhibiting voltage-gated sodium channels.
• Membrane Permeabilization: Stabilizes nerve membranes, reducing excitability.

Uses

• Topical Anesthesia: Applied to mucous membranes and skin for numbing before minor procedures.
• Ophthalmic Anesthesia: Used in eye surgeries for corneal numbing.
• Dental Preparations: Incorporated in gels and creams for dental applications.

Side Effects of Butamben

• Local Irritation: Redness and mild irritation at the application site.
• Allergic Reactions: Rare but possible in sensitive individuals.

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