Glimepiride

Glimepiride is a third-generation sulfonylurea antidiabetic drug widely used in type 2 diabetes treatment. It lowers blood sugar by stimulating pancreatic insulin secretion and is considered more effective and safer than earlier sulfonylureas, offering better glycemic control with a lower risk of side effects.

Structure of Glimepiride

• Glimepiride is a third-generation sulfonylurea with a triazole ring, providing enhanced selectivity and reduced side effects.
• Chemical Formula: C₂₁H₂₄ClN₅O₃S

Mode of Action

• Enhanced Selectivity: More selective for pancreatic beta cells, reducing off-target effects.
• Increased Potency: Lower doses achieve desired insulinotropic effects.

Uses

• Type 2 Diabetes Mellitus: Improves glycemic control with lower risk of hypoglycemia.
• Combination Therapy: Used alongside other antidiabetic agents for synergistic effects.

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