Herbal Disintegrants

• Disintegrants are substances that help tablets break apart (disintegrate) into smaller particles after administration, facilitating the release and absorption of the active ingredient in the body.

Significance

1. Drug Bioavailability: Effective disintegration is critical for quick release and hence prompt onset of action.

2. Efficient Dosage Form: Ensures consistent and reliable performance of solid oral dosage forms.

illustration of Herbal Disintegrants

Examples & Uses

• Starch (corn, potato, rice): Swells upon contact with water, causing tablet disintegration.

• Isapghula husk (Plantago ovata): Exhibits excellent swelling properties, promoting rapid disintegration.

• Agar agar (from seaweeds): Used as a disintegrant due to swelling action.