Idiosyncrasy

Idiosyncrasy in pharmacology refers to an unusual and unpredictable drug reaction that is not dose-dependent and often genetically determined. Such drug responses vary among individuals, where most patients tolerate the medicine, but certain susceptible people may experience harmful effects. For example, Primaquine can cause hemolysis in individuals with G6PD deficiency, highlighting how genetic factors influence idiosyncratic reactions.

Definition of Idiosyncrasy:

• It refers to an unusual or unexpected response to a drug that is:
• Unpredictable
• Not dose-dependent
• Often genetically determined

Example:

• Primaquine can cause hemolysis in people with G6PD deficiency.
• Reaction may be harmless in most, but dangerous in susceptible individuals.

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