Introduction to Transdermal Drug Delivery Systems (TDDS)

• Transdermal Drug Delivery Systems (TDDS) are self-contained, discrete dosage forms designed to deliver drugs through the skin at a controlled rate directly into the systemic circulation.

• These systems, commonly available as patches or gels, provide a non-invasive and effective method for administering medications.

Transdermal Drug Delivery Systems (TDDS)

Advantages

1. Bypass First-Pass Metabolism: Avoids liver metabolism, reducing drug degradation.

2. Sustained Release: Maintains constant drug levels, improving effectiveness and reducing side effects.

3. Patient-Friendly: Non-invasive, convenient, and reduces dosing frequency.

4. Less Side Effects: Targeted delivery minimizes systemic side effects.

5. Easy Termination: Therapy can be stopped by simply removing the patch.

Disadvantages of Transdermal Drug Delivery Systems

1. Skin Irritation: May cause local reactions.

2. Skin Barrier: The outer skin layer limits drug penetration.

3. Drug Suitability: Only works for potent drugs with specific properties.

4. Drug Residue: Wastage may occur due to leftover drug in the patch.

5. Visibility: Some patients may find patches cosmetically unappealing.

TDDS offers a non-invasive alternative for drug delivery but has limitations related to drug properties and skin compatibility.