Methacholine

• Methacholine is a synthetic choline ester, and a non-selective muscarinic receptor agonist used primarily for diagnostic purposes.
• It mimics the action of acetylcholine on muscarinic receptors, particularly in the lungs and smooth muscles.

Chemical Formula:

• C₈H₁₈ClNO₂

Mechanism of Action:

• Selective muscarinic agonist
• Slightly longer acting than ACh due to beta-methyl resistance to AChE.

Uses of Methacholine:

• Diagnosis of bronchial hyperreactivity (asthma test) via inhalation.

Side Effects of Methacholine:

• Hypotension
• Bradycardia
• Bronchospasm
• Flushing

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