Nateglinide

Nateglinide is a meglitinide antidiabetic drug used in the treatment of type 2 diabetes mellitus. It lowers blood sugar by stimulating rapid insulin release from the pancreas, making it particularly effective in controlling post-meal glucose levels. With its fast onset and short duration of action, Nateglinide helps improve glycemic control while reducing the risk of prolonged hypoglycemia.

Structure of Nateglinide

• It is a meglitinide with a pyridine and indole ring system, providing enhanced specificity for pancreatic K⁺
• Chemical Formula: C₁₇H₁₈N₂O

Mode of Action

• Similar to Repaglinide: Stimulates insulin secretion by blocking K⁺
• Rapid Onset and Short Duration: Effective in managing postprandial hyperglycemia with minimal risk of hypoglycemia.

Uses

• Type 2 Diabetes Mellitus: Regulates postprandial blood glucose spikes.
• Combination Therapy: Utilized alongside other antidiabetic medications for optimal glycemic management.

Thank you for reading from Firsthope's notes, don't forget to check YouTube videos!