Pioglitazone

Pioglitazone is a thiazolidinedione antidiabetic drug that improves insulin sensitivity and controls blood sugar in type 2 diabetes.

Structure of Pioglitazone

• Pioglitazone is a TZD with a thiazolidinedione ring substituted with a pyridine moiety, enhancing its binding affinity to PPAR-γ.
• Chemical Formula: C₁₄H₁₈N₂O₂S

Mode of Action

• PPAR-γ Agonism: Enhances insulin sensitivity by modulating gene expression related to glucose and lipid metabolism.
• Adipocyte Differentiation: Promotes the formation of insulin-sensitive adipocytes.

Uses

• Type 2 Diabetes Mellitus: Improves glycemic control by increasing insulin sensitivity.
• Dyslipidemia: Reduces triglycerides and increases HDL cholesterol levels.
• Non-Alcoholic Steatohepatitis (NASH): Investigated for its role in reducing liver fat and inflammation.

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