Proguanil
- BP-S-6-Medicinal Chemistry III
- Mar 28
- 1 min read
Chemical Structure / Formula of Proguanil
Formula: C11H16ClN5
Structure: A biguanide that is metabolized into Cycloguanil (active form).
Mechanism of Action
Inhibits dihydrofolate reductase (DHFR) in Plasmodium, blocking folate metabolism and DNA synthesis.
Uses
Malaria prophylaxis, especially in combination with Atovaquone (Malarone®).
Side Effects
GI upset, mild hepatotoxicity, mouth ulcers.
Rarely causes pancytopenia in long-term use.
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