Repaglinide

Repaglinide is a meglitinide antidiabetic drug commonly used in the management of type 2 diabetes mellitus. It lowers blood sugar by stimulating quick and short-acting insulin release from the pancreas, particularly effective in controlling postprandial (after-meal) glucose spikes. With its rapid onset and short duration of action, Repaglinide offers flexibility in dosing and is especially useful for patients requiring targeted blood sugar control around meals.

Structure of Repaglinide

• Repaglinide is a meglitinide derivative with a pyridine ring, enhancing its binding affinity to pancreatic K⁺
• Chemical Formula: C₁₀H₁₂N₂O

Mode of Action

• K⁺ Channel Blockade: Stimulates insulin release by blocking ATP-sensitive K⁺ channels in pancreatic beta cells.
• Rapid Onset and Short Duration: Targets postprandial hyperglycemia without causing prolonged hypoglycemia.

Uses

• Type 2 Diabetes Mellitus: Controls postprandial blood glucose levels.
• Combination Therapy: Often used with metformin or other antidiabetic agents for comprehensive glycemic control.

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