Rosiglitazone

Rosiglitazone is a thiazolidinedione antidiabetic drug that enhances insulin sensitivity to help manage blood sugar in type 2 diabetes.

Structure of Rosiglitazone

• It is a TZD with a similar core structure to pioglitazone but contains a different aromatic substituent, enhancing its potency.
• Chemical Formula: C₁₉H₂₅N₃O₃S

Mode of Action

• PPAR-γ Agonism: Increases insulin sensitivity in peripheral tissues.
• Anti-Inflammatory Effects: Reduces inflammatory markers associated with insulin resistance.

Uses of Rosiglitazone

• Type 2 Diabetes Mellitus: Enhances insulin sensitivity to improve glycemic control.
• Metabolic Syndrome: Assists in managing insulin resistance and dyslipidemia.

Note

• Cardiovascular Risks: Associated with increased risk of myocardial infarction; usage restricted or monitored closely in many regions.

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