• Serratiopeptidase is a proteolytic enzyme with strong anti-inflammatory and pain-relieving properties.
  • Serratiopeptidase aids in reducing swelling, easing pain, and promoting faster tissue healing.

General Information

  • Synonyms: Serrapeptase, Serratiopeptidase
  • Biological Source:
    • Derived from Serratia marcescens (bacteria).
  • Family: Enterobacteriaceae
  • Geographical Source:
    • Found in Japan, India, USA, China, Germany.

Macroscopical Characters

  • Color: White to off-white powder.
  • Texture: Fine, crystalline.
  • Taste: Tasteless.
  • Odor: Odorless.

Chemical Constituents

  • Proteolytic enzyme: Serratiopeptidase (Metalloprotease).
  • Other components: Zinc, Magnesium (for enzymatic activity).
  • Molecular weight: ~60,000 Da

Mechanism of Action

Serratiopeptidase breaks down inflammatory proteins and fibrin, reducing swelling and pain. It also clears mucus and biofilms in infections.

Preparation

  1. Bacterial Fermentation:
    • Serratia marcescens is cultured in a nutrient medium.
  2. Purification:
    • Enzyme is isolated using centrifugation and precipitation methods.
  3. Drying & Packaging:
    • Freeze-dried and formulated into tablets/capsules.

Evaluation

  • Solubility: Soluble in water.
  • Purity Tests:
    • Proteolytic Activity Test using casein.

Preservation & Storage

  • Stored at 4°C in airtight containers.

Therapeutic Uses

  • Anti-inflammatory (treats swelling, pain).
  • Mucolytic agent (reduces mucus thickness in lung diseases).
  • Blood thinner (prevents blood clot formation).

Commercial Utility

  • Used in pharmaceuticals (pain relief, enzyme therapy).
  • Used in respiratory medicine (reduces mucus in bronchitis).

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