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Sulphadiazine

Chemical Structure / Formula of Sulphadiazine

  • Formula: C10H10N4O2S

  • Structure: Sulfonamide group with a diazine ring.

Chemical Structure of Sulphadiazine

Mechanism of Action

  • Inhibits dihydropteroate synthase, interfering with folate synthesis.

  • Bacteriostatic action.

Uses

  • Used with pyrimethamine for toxoplasmosis.

  • Treats malaria, meningitis, and urinary tract infections.

  • Broad-spectrum activity against Gram-positive and Gram-negative bacteria.

Side Effects

  • Nausea, vomiting, hypersensitivity reactions.

  • Crystalluria, risk of renal damage (hydrate well).

  • Photosensitivity, hematologic toxicity.


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