Tachyphylaxis

Tachyphylaxis is a rapid decrease in drug response after repeated doses in a short period, leading to reduced effectiveness.

Definition of Tachyphylaxis:

• Tachyphylaxis is a rapid decrease in drug response after repeated administration in a short time.

Key Features:

• Occurs quickly (within minutes to hours).
• Further dosing does not restore the effect.

Mechanism:

• Possible depletion of neurotransmitter stores.
• Desensitization or inactivation of receptors.

Example of Tachyphylaxis:

• Ephedrine (indirect sympathomimetic): Causes tachyphylaxis due to depletion of norepinephrine.

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