• Teratogens are substances that cause birth defects (congenital anomalies) during fetal development. Many natural, plant-derived compounds have been found to exhibit teratogenic effects.
  • Teratogens identification helps prevent congenital disorders and ensures safe drug use during pregnancy.
  • The following section details common teratogenic agents, their sources, and the effects they cause.

Common Teratogenic Plant Compounds:

Teratogenic Agent Source Effects
Thalidomide-like Alkaloids Veratrum album (False hellebore) (family Melanthiaceae) Causes limb deformities
Pyrrolizidine Alkaloids Crotalaria, Senecio, Heliotropium species (family Asteraceae, Boraginaceae) Liver toxicity, fetal growth restriction
Retinoids (Vitamin A analogs) Plants rich in β-carotene, such as carrots and sweet potatoes Craniofacial and heart defects
Mycotoxins (Aflatoxins, Fumonisins) Fungi contaminating cereals, nuts Neural tube defects, stillbirths

Teratogenic effects are dose-dependent and occur when the fetus is exposed during critical periods of organogenesis.

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