Pharmaceutical Engineering

Theories & Factors influencing filtration

Theories & Factors influencing filtration

  • Factors influencing filtration revolve around separating solid particles from liquid or gas using a porous medium

Poiseuille’s Equation

  • Poiseuille’s equation describes the laminar flow of a fluid through a cylindrical pipe, often applied to describe the flow through the pores of a filter medium.
  • $Q = \frac{\pi r^4 \Delta P}{8 \eta L}$
  • Where:
    • Q = flow rate
    • r = radius of the pore
    • ΔP = pressure drop across the filter
    • η = viscosity of the fluid
    • L = length of the pore

Darcy’s Equation

  • Darcy’s equation describes the flow of a fluid through a porous medium, useful for understanding filtration through filter cakes and media.
$Q = \frac{kA \Delta P}{\eta L}$
  • Where:
    • Q = flow rate
    • k = permeability of the medium
    • A = cross-sectional area
    • ΔP = pressure drop across the medium
    • η = viscosity of the fluid
    • L = thickness of the medium

Carman-Kozeny Equation

  • The Carman-Kozeny equation is an extension of Darcy’s law that takes into account the characteristics of the filter cake, such as particle size and porosity.
  • $
    \frac{\Delta P}{L} = \frac{180 \, \eta \, (1 – \varepsilon)^2}{d_p^2 \, \varepsilon^3} \cdot v
    $
  • Where:
    • ΔP = pressure drop
    • L = thickness of the filter cake
    • η = viscosity of the fluid
    • ϵ = porosity of the cake
    • dp​ = diameter of the particles
    • v = superficial velocity of the fluid

Factors Influencing Filtration

  1. Particle Size and Distribution: Larger particles are generally easier to filter, while a wide size distribution can complicate the process.
  2. Filter Medium Properties: Pore size, surface area, and material of the filter medium affect the efficiency and type of filtration.
  3. Flow Rate: Higher flow rates can lead to lower filtration efficiency as particles may pass through the filter medium.
  4. Viscosity of the Fluid: Higher viscosity fluids are harder to filter.
  5. Temperature: Temperature can affect fluid viscosity and the properties of the filter medium.
  6. Pressure Drop: The difference in pressure across the filter medium influences the filtration rate.
  7. Solid Concentration: Higher solid concentrations can lead to faster clogging of the filter medium.

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