Types of microbial contaminants include a diverse range of microorganisms such as bacteria, viruses, fungi, and protozoa.

Bacteria in Types of Microbial Contaminants:

  • Gram-Positive Bacteria

    • Examples: Staphylococcus aureus, Bacillus subtilis.
    • Characteristics: Resistant to drying; some form spores.
  • Gram-Negative Bacteria

    • Examples: Pseudomonas aeruginosa, Escherichia coli.
    • Characteristics: Often found in water; can be resistant to preservatives.

Fungi:

  • Molds

    • Examples: Aspergillus niger, Penicillium
    • Characteristics: Produce spores; can grow in low aw environments.
  • Yeasts

    • Examples: Candida albicans, Saccharomyces cerevisiae.
    • Characteristics: Can grow in acidic environments; cause fermentation.

Spores:

  • Definition: Dormant, resistant forms of bacteria and fungi.
  • Impact: Resistant to heat and chemical disinfectants.
  • Control: Requires stringent sterilization methods like autoclaving.

Viruses and Mycoplasmas:

  • Less Common: Generally, not a major concern in pharmaceutical spoilage but important in biological products.

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