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Zalcitabine (ddC)

Chemical Structure / Formula of Zalcitabine (ddC)

  • Formula: C9H13N3O3

  • Structure: A cytosine analog without a 3'-OH group, causing chain termination.

Chemical Structure of Zalcitabine (ddC)

Mechanism of Action

  • Phosphorylated into Zalcitabine triphosphate, which inhibits HIV reverse transcriptase and leads to chain termination.

Uses

  • HIV/AIDS therapy (HAART regimen, rarely used now).

Side Effects

  • Peripheral neuropathy (most common).

  • Lactic acidosis, pancreatitis.

  • Mouth ulcers, hepatotoxicity.


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