Benoxinate

Benoxinate is an ester local anesthetic mainly used in ophthalmology to numb the eye surface for diagnostic procedures.

Structure of Benoxinate

• It is an amino benzoic acid derivative with a butyl ester group, primarily used in ophthalmic preparations for its local anesthetic properties.
• Chemical Formula: C₁₂H₂₀N₂O₂

Mode of Action

• Sodium Channel Inhibition: Blocks voltage-gated sodium channels in corneal nerves, preventing pain signal transmission.
• Membrane Stabilization: Reduces nerve excitability by stabilizing nerve membranes.

Uses

• Ophthalmic Anesthesia: Applied as eye drops to numb the cornea before eye surgeries, injections, or diagnostic procedures.
• Minor Eye Procedures: Used in non-surgical interventions requiring temporary corneal numbing.

Side Effects of Benoxinate

• Local Irritation: May cause eye redness, stinging, or discomfort.
• Systemic Absorption: Minimal, but potential for allergic reactions in sensitive individuals.

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