Benzocaine

Benzocaine is an ester-type local anesthetic commonly used topically to relieve pain and itching by blocking nerve signals.

Structure of Benzocaine

• Benzocaine is a simple amino benzoic acid derivative with a diethylamino group attached to the benzene ring, enhancing its lipophilicity and anesthetic properties.
• Chemical Formula: C₇H₉NO₂

Mode of Action

• Sodium Channel Blockade: Inhibits voltage-gated sodium channels, preventing nerve impulse conduction.
• Membrane Stabilization: Alters nerve membrane permeability, reducing excitability.

Uses

• Topical Anesthesia: Applied to mucous membranes, skin, and minor cuts for numbing.
• Oral Preparations: Used in throat lozenges and sprays to alleviate sore throat pain.
• Dental Anesthesia: Utilized in gels and creams for minor dental procedures.

Structure-Activity Relationship (SAR)

• Diethylamino Group: Increases lipophilicity, enhancing membrane permeability and anesthetic potency.
• Ester Group: Facilitates rapid hydrolysis and onset of action.
• Benzene Ring Substitution: Modifications can affect duration and potency of anesthesia.

Synthesis of Benzocaine

Thank you for reading from Firsthope's notes, don't forget to check YouTube videos!