Dibucaine

Dibucaine is a potent amide local anesthetic used topically for pain relief and hemorrhoid treatment.

Structure of Dibucaine

• It is a potent amino benzoic acid derivative with a butyl ester group, providing long-lasting local anesthetic effects.
• Chemical Formula: C₁₀H₂₀N₂O₂

Mode of Action

• Sodium Channel Blockade: Inhibits voltage-gated sodium channels, preventing nerve impulse conduction.
• Membrane Stabilization: Enhances nerve membrane stability, reducing excitability.

Uses

• Topical Anesthesia: Applied in rectal preparations, hemorrhoid treatments, and skin procedures for prolonged numbing.
• Local Anesthesia: Used in minor surgical procedures requiring extended anesthesia.
• Dermatological Applications: Employed in creams and ointments for skin conditions requiring local pain relief.

Side Effects

• Local Irritation: Redness, swelling, or discomfort at the application site.
• Systemic Toxicity: CNS excitation (e.g., seizures) and cardiovascular disturbances in high doses.

Synthesis of Dibucaine

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