Physical Pharmaceutics I Notes (S-3)
Physical Pharmaceutics I Notes
Below are well-organized, unit-wise Physical Pharmaceutics notes available for free.
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Unit 1
Solubility of Drugs
Unit I covers drug solubility, solute-solvent interactions, ideal solubility, solvation, and factors affecting solubility. Topics include gas and liquid solubility, Raoult’s law, real and ideal solutions, partially miscible liquids, CST, and distribution law.
Unit 2
States & Properties of Matter
Unit II covers states and properties of matter including phase changes, vapor pressure, eutectic mixtures, aerosols, liquid crystals, and polymorphism. It also includes physicochemical properties like refractive index, optical rotation, dipole moment, and dissociation constant.
Unit 3
Surface, Interfacial Phenomenon
Unit III covers surface and interfacial phenomena, including surface and interfacial tension, surface free energy, spreading coefficient, adsorption at interfaces, surface active agents, HLB scale, solubilization, detergency, and adsorption at solid interfaces.
Unit 4
Complexation & Protein Binding
Unit IV covers complexation and protein binding, including types and classification of complexes, their applications, analysis methods, drug interactions, crystalline structures, and thermodynamic stability constants.
Unit 5
pH, Buffers & Isotonic Solutions
Unit V covers pH, buffers, and isotonic solutions, including Sorensen’s pH scale, pH determination methods, buffer equations, buffer capacity, and applications in pharmaceutical and biological systems, along with preparation of buffered isotonic solutions.
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