S-4 Medicinal Chemistry I - Free Notes | Pharmacy

Medicinal Chemistry I Notes (S-4)

Medicinal Chemistry I Notes

Below are well-organized, unit-wise Medicinal Chemistry I notes available for free.
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Unit 1

Introduction to Medicinal Chemistry

Introduces medicinal chemistry, its history, and development. Discusses physicochemical properties like ionization, solubility, partition coefficient, hydrogen bonding, and bioisosterism. Covers drug metabolism (Phase I & II) and stereochemical factors.

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Unit 2

Drugs Acting on the Adrenergic Nervous System

Unit 2 Covers drugs acting on the autonomic nervous system, focusing on adrenergic neurotransmitters, their biosynthesis and catabolism. alpha- and beta-adrenergic receptors and their distribution. Includes SAR and examples of sympathomimetic agents (direct, indirect), and adrenergic antagonists such as alpha and beta blockers, along with their medicinal applications.

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Unit 3

Cholinergic neurotransmitters

Unit 3 Covers cholinergic neurotransmitters including biosynthesis and catabolism of acetylcholine. Discusses muscarinic and nicotinic receptors and their distribution. Includes SAR and examples of parasympathomimetic agents (direct and indirect acting), cholinesterase inhibitors (reversible and irreversible), and cholinesterase reactivator pralidoxime. Also covers cholinergic blocking agents, including natural alkaloids and synthetic analogues with their medicinal relevance.

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Unit 4

Drugs acting on Central Nervous System

This Unit includes CNS-acting drugs including sedatives and hypnotics like benzodiazepines (e.g., diazepam) and barbiturates (e.g., phenobarbital), along with other classes like carbamates and aldehydes. Discusses antipsychotics including phenothiazines, ring analogues, butyrophenones, and benzamides.

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Unit 5

CNS Drugs: Anesthetics, Analgesics and Anti-Inflammatories

Covers CNS drugs including general anesthetics like inhalation agents (halothane, sevoflurane), ultra-short acting barbiturates, and dissociative anesthetics (ketamine). Discusses narcotic and non-narcotic analgesics including morphine analogues, their SAR, and antagonists like naloxone. Also includes anti-inflammatory agents such as aspirin, ibuprofen, diclofenac, and acetaminophen with therapeutic relevance.

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