S-6 Medicinal Chemistry III - Unit Wise Free Notes

Medicinal Chemistry III Notes (S-6)

Medicinal Chemistry III Notes

Below are well-organized, unit-wise Medicinal Chemistry III notes available for free.
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Unit 1

Antibiotics & Aminoglycosides

Overview of antibiotics: history, naming, stereochemistry, SAR, degradation, and key drugs. Covers β-lactams (penicillins, cephalosporins, inhibitors, monobactams), aminoglycosides (streptomycin, neomycin, kanamycin), and tetracyclines (e.g., doxycycline).

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Unit 2

Antibiotics & Antimalarials: Structures & SAR

Covers antibiotics (e.g., chlortetracycline, macrolides, chloramphenicol), prodrug concepts, and antimalarials: etiology, SAR of quinolines, biguanides, triazines, and key drugs like chloroquine, mefloquine, artesunate, and pyrimethamine.

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Unit 3

Anti-TB, UTI & Antiviral Agents

Covers anti-TB drugs (e.g., isoniazid, rifampicin, streptomycin), urinary tract agents (quinolones, nitrofurantoin), and antivirals like acyclovir, zidovudine, lamivudine, saquinavir, and ritonavir, with SAR and classifications.

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Unit 4

Antifungals, Antiprotozoals & Sulfonamides

Covers antifungals (e.g., amphotericin-B, azoles), antiprotozoals (e.g., metronidazole), anthelmintics (e.g., albendazole, ivermectin), fluoroquinolone gatifloxacin, and sulfonamides/sulfones with SAR, key drugs, and classifications.

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Unit 5

Intro to Drug Design & QSAR Approaches

Introduction to drug design: approaches, QSAR parameters (log P, Hammett, Taft, Hansch), pharmacophore modeling, docking, and combinatorial chemistry with applications in solid-phase and solution-phase synthesis.

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