S-6 Biopharmaceutics & Pharmacokinetics

Biopharmaceutics & Pharmacokinetics Notes (S-6)

Biopharmaceutics & Pharmacokinetics Notes

Below are well-organized, unit-wise Biopharmaceutics & Pharmacokinetics notes available for free.
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Unit 1

Biopharmaceutics: Absorption & Distribution

Overview of biopharmaceutics covering drug absorption mechanisms via GIT and non-oral routes, factors affecting absorption, drug distribution, tissue permeability, protein binding dynamics, and clinical relevance of protein-drug interactions.

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Drug Elimination in Biopharmaceutics & Pharmacokinetics

Unit 2

Drug Elimination, Bioavailability & Bioequivalence

Covers drug elimination via metabolism and renal/non-renal excretion, factors affecting renal clearance, and concepts of bioavailability and bioequivalence, including IVIVC, and techniques to improve poorly soluble drug absorption.

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Unit 3

Pharmacokinetics Models, Dosing & Parameters

Introduction to pharmacokinetics, covering compartment, non-compartment, and physiological models. Includes one-compartment open model for IV bolus, infusion, and extravascular routes. Key parameters, their definitions, significance, and applications.

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Unit 4

Multicompartment models

Explores two-compartment open models, kinetics of multiple dosing, steady-state drug levels, and calculation of loading and maintenance doses, highlighting their clinical significance and application.

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Unit 5

Nonlinear Pharmacokinetics

Introduction to nonlinear pharmacokinetics, factors causing non-linearity, and the Michaelis-Menten method for parameter estimation, with examples of drugs exhibiting nonlinear behavior.

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