Complexation & protein binding

• Introduction to Complexation & Protein Binding
• Classification of Complexation
• Applications of Complexation
• Methods of Analysis for Complexes
• Protein Binding
• Complexation and Drug Action
• Crystalline Structures of Complexes
• Thermodynamic Treatment of Stability Constants

Other Units of Physical Pharmaceutics I

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Physical Pharmaceutics I

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Other Subjects of B Pharmacy 3rd Semester

Unit IV Summary: Complexation & Protein Binding

Unit IV explores the concept of complexation and its significance in pharmaceutical sciences. It begins with an introduction to complex formation, explaining how drug molecules can form complexes with other substances, thereby altering their physical and chemical properties. The classification of complexes is discussed, including metal complexes, inclusion complexes, and organic molecular complexes.

The unit highlights the applications of complexation in drug formulation, solubility enhancement, stability, and controlled release. It also describes various methods of analyzing complexes, such as spectroscopy and electrochemical techniques.

A major focus is placed on protein binding, which influences a drug’s distribution, efficacy, and elimination from the body. The relationship between complexation and drug action is examined, especially how binding can affect bioavailability and therapeutic activity.

Finally, the unit covers the crystalline structures of complexes and the thermodynamic aspects of stability, including the determination of stability constants, which help evaluate the strength and feasibility of complex formation in pharmaceutical preparations

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