Pharmacology of Drugs acting on CNS U-4 Notes

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Pharmacology of drugs acting on central nervous system

  • Introduction to CNS
  • Neurohumoral Transmission In The CNS
  • γ-Aminobutyric Acid (GABA)
  • Glutamate
  • Glycine
  • Serotonin (5-HT)
  • Dopamine (DA)
  • General Anesthetics
  • Inhalational General Anesthetics
  • Intravenous (IV) Anesthetics
  • Pre-anesthetics
  • Sedatives and Hypnotics
  • Centrally Acting Muscle Relaxants
  • Seizures and Their Types
  • Anti-Epileptic Drugs (AEDS)
  • Alcohol (Ethanol)
  • Disulfiram (Antabuse)

Other Units of Pharmacology I

Unit 1
Unit 2
Unit 3
Unit 5
Pharmacology I

Other Subjects of B Pharmacy 4th Semester

Topic wise notes of:

Medicinal Chemistry I

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Topic wise notes of:

Physical Pharmaceutics II

  • Colloidal dispersions
  • Rheology & Deformation of solids
  • Coarse dispersion
  • Micromeretics
  • Drug stability
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Topic wise notes of:

Pharmacognosy & Phytochemistry I

  • Pharmacognosy: Sources, Classification, and Quality Control
  • Conservation and Cultivation of Medicinal Plants
  • Plant tissue culture
  • Role of Pharmacognosy and Secondary Metabolites
  • Drugs of Natural Origin: Plant, Marine, and Primary Metabolites
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Topic wise notes of:

Pharmaceutical Organic Chemistry III

  • Stereo isomerism
  • Geometrical isomerism
  • Heterocyclic compounds
  • Heterocycles: Synthesis, Reactions & Uses
  • Reactions of synthetic importance
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Pharmacology of Drugs Acting on the Central Nervous System – Summary

Unit IV explores the pharmacology of drugs acting on the central nervous system (CNS), highlighting the intricate mechanisms of neurohumoral transmission. The unit begins by examining key CNS neurotransmitters such as GABA, glutamate, glycine, serotonin, and dopamine, each playing a significant role in mood regulation, motor control, and neuronal excitability. Understanding these neurotransmitters is crucial for developing CNS-acting drugs.

The unit then discusses general anesthetics and pre-anesthetics, which induce and prepare for surgical anesthesia by depressing CNS activity. It also includes sedatives and hypnotics, which reduce anxiety and induce sleep, respectively, as well as centrally acting muscle relaxants, which alleviate muscle spasms by modulating spinal or supraspinal pathways.

Furthermore, it covers anti-epileptic drugs, detailing their mechanisms in controlling seizures through modulation of neuronal excitability and synaptic transmission. This section emphasizes the importance of selecting appropriate drugs based on seizure type and patient profile.

Lastly, the unit reviews the pharmacology of alcohols, including their CNS depressant effects, and the role of disulfiram, a deterrent used in alcohol dependence therapy. This unit provides a comprehensive foundation in understanding how various CNS drugs influence brain function and clinical outcomes.

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