Drugs acting on Central Nervous System U-4 Notes

Buy Premium

Get The High-Quality Pdf Notes on App

Drugs acting on Central Nervous System
Sedatives and Hypnotics

  • Sedatives and Hypnotics
  • SAR of Benzodiazepines (BZDs)
  • SAR of Barbiturates

Various Benzodiazepines

  • Chlordiazepoxide
  • Diazepam
  • Oxazepam
  • Clorazepate Dipotassium
  • Lorazepam
  • Alprazolam
  • Zolpidem (non-benzodiazepine hypnotic)

Various Barbiturates

  • Barbital (Veronal)*
  • Phenobarbital
  • Mephobarbital
  • Amobarbital
  • Butabarbital
  • Pentobarbital
  • Secobarbital

Amides & Imides

  • Glutethimide

Alcohols & Their Carbamate Derivatives

  • Meprobamate
  • Ethchlorvynol

Aldehydes & Derivatives

  • Triclofos Sodium
  • Paraldehyde

Antipsychotics

  • Antipsychotic Agents

Various Phenothiazines Drugs

  • Promazine Hydrochloride
  • Chlorpromazine Hydrochloride
  • Triflupromazine
  • Thioridazine Hydrochloride
  • Piperacetazine Hydrochloride
  • Prochlorperazine Maleate
  • Trifluoperazine Hydrochloride

Various Ring Analogues of Phenothiazines

  • Chlorprothixene
  • Thiothixene
  • Loxapine Succinate
  • Clozapine

Various Fluorobutyrophenones

  • Haloperidol
  • Droperidol
  • Risperidone
  • Molindone Hydrochloride
  • Sulpiride

Anticonvulsants

  • Anticonvulsants

Various Barbiturates (Anticonvulsant Use)

  • Phenobarbitone (Phenobarbital)
  • Metharbital

Various Hydantoins

  • Phenytoin*
  • Mephenytoin
  • Ethotoin

Various Oxazolidine Diones

  • Trimethadione
  • Paramethadione

Various Succinimides

  • Ethosuximide*
  • Phensuximide
  • Methsuximide

Various Urea & Monoacylureas

  • Phenacemide
  • Carbamazepine*
  • Clonazepam

Various Miscellaneous Antiepileptics

  • Primidone
  • Valproic Acid
  • Gabapentin
  • Felbamate

Other Units of Medicinal Chemistry I

Unit 1
Unit 2
Unit 3
Unit 5
Medicinal Chemistry I

Other Subjects of B Pharmacy 4th Semester

Topic wise notes of:

Pharmacology I

  • Introduction to Pharmacology & Pharmacokinetics
  • Pharmacodynamics & Drug Interaction
  • Pharmacology of drugs acting on peripheral nervous system
  • Pharmacology of drugs acting on central nervous system-1
  • Psychotropic Drugs
Select

Topic wise notes of:

Physical Pharmaceutics II

  • Colloidal dispersions
  • Rheology & Deformation of solids
  • Coarse dispersion
  • Micromeretics
  • Drug stability
Select

Topic wise notes of:

Pharmacognosy & Phytochemistry I

  • Pharmacognosy: Sources, Classification, and Quality Control
  • Conservation and Cultivation of Medicinal Plants
  • Plant tissue culture
  • Role of Pharmacognosy and Secondary Metabolites
  • Drugs of Natural Origin: Plant, Marine, and Primary Metabolites
Select

Topic wise notes of:

Pharmaceutical Organic Chemistry III

  • Stereo isomerism
  • Geometrical isomerism
  • Heterocyclic compounds
  • Heterocycles: Synthesis, Reactions & Uses
  • Reactions of synthetic importance
Select

Drugs Acting on the Central Nervous System – Summary

Unit IV focuses on the pharmacology and medicinal chemistry of drugs acting on the central nervous system (CNS), with an emphasis on sedatives, hypnotics, antipsychotics, and anticonvulsants. It begins with sedatives and hypnotics, particularly benzodiazepines such as diazepam, lorazepam, and zolpidem. The Structure-Activity Relationship (SAR) of benzodiazepines is discussed to explain how structural variations affect their potency and activity.

It also covers barbiturates like phenobarbital and secobarbital, detailing their SAR and clinical use in inducing sedation and sleep. Additional CNS depressants include amides, imides, alcohol derivatives, and aldehyde-based agents like glutethimide, meprobamate, and paraldehyde.

In the antipsychotic category, the unit explores phenothiazines (e.g., chlorpromazine), their SAR, and analogues such as chlorprothixene, haloperidol, risperidone, and clozapine, which are used to manage schizophrenia and other psychotic disorders.

Lastly, the unit covers anticonvulsants, including their SAR and mechanism of action. Drug classes include barbiturates, hydantoins (phenytoin), oxazolidine diones, succinimides, and ureas. Newer agents like valproic acid, gabapentin, clonazepam, and carbamazepine are also discussed. This unit provides an integrated understanding of CNS drug classes, mechanisms, and chemical properties essential for therapeutic application.

Overall, this unit gives a thorough understanding of cholinergic pharmacology and its clinical applications.

At FirstHope, we provide BPharm notes that are topic-wise, easy to understand, and designed strictly as per the AKTU and Other Universities, hence designed according to PCI syllabus.

Thank you for reading from Firsthope's notes, don't forget to check YouTube videos!