Polynuclear Hydrocarbons U-4 Notes
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Polynuclear hydrocarbons
Other Units of Pharmaceutical Organic Chemistry II
Pharmaceutical organic chemistry II
Other Subjects of B Pharmacy 3rd Semester
Topic wise notes of:
Pharmaceutical Engineering
Topic wise notes of:
Pharmaceutical Microbiology
- Microbiology and Bacterial Cultivation Techniques
- Sterilization Techniques and Staining Methods
- Fungi, Viruses, and Sterility
- Aseptic Area and Assay Methods
- Microbial Spoilage & Cell Culture
Unit IV Summary: Polynuclear Hydrocarbons
This unit focuses on polynuclear hydrocarbons, which are aromatic compounds containing two or more fused benzene rings. These compounds are important due to their unique chemical structures, characteristic reactions, and significant medicinal applications.
The unit begins with the synthesis and general chemical reactions of polynuclear hydrocarbons. Like benzene, these compounds undergo electrophilic substitution reactions such as nitration, sulphonation, halogenation, and Friedel-Crafts alkylation and acylation. However, their reactivity patterns are influenced by the number and arrangement of fused rings, making them slightly more reactive or selective compared to monoaromatic compounds.
The unit covers the structure and medicinal uses of several key polynuclear hydrocarbons including naphthalene, phenanthrene, anthracene, diphenylmethane, and triphenylmethane, along with their derivatives. Naphthalene is widely used in insecticides and antiseptics. Phenanthrene forms the core structure of many biologically active compounds such as steroids. Anthracene is used in dye production and has photochemical relevance in pharmaceuticals. Diphenylmethane and triphenylmethane derivatives serve as intermediates in the synthesis of dyes, antimicrobials, and antiseptics.
These hydrocarbons and their derivatives are essential in the development of several therapeutic agents due to their stable aromatic systems and ability to interact with biological targets. The unit emphasizes understanding the relationship between chemical structure, reactivity, and biological activity, providing a foundation for further study in medicinal and organic chemistry. This knowledge aids in drug design and the synthesis of complex organic molecules with pharmaceutical applications.
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