pH, Buffers, and Isotonic Solutions

• pH
• Sorensen’s pH Scale
• pH Determination
• Buffers
• Applications of Buffers
• Buffer Equation
• Buffer Capacity
• Buffers in Pharmaceutical and Biological Systems
• Buffered Isotonic Solutions
• Methods to Determine Isotonicity
• Methods of Adjusting Isotonicity

Other Units of Physical Pharmaceutics I

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Physical Pharmaceutics I

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Other Subjects of B Pharmacy 3rd Semester

Unit V Summary: pH, Buffers, and Isotonic Solutions

This unit focuses on the fundamental concepts of pH, buffer systems, and isotonic solutions, which are essential in pharmaceutical and biological applications. It begins with Sorensen’s pH scale, explaining the importance of hydrogen ion concentration in measuring acidity or alkalinity.

The unit covers methods for pH determination, including electrometric (using pH meters) and colorimetric (using indicators) techniques. It then explores the buffer equation and buffer capacity, highlighting how buffers resist changes in pH upon the addition of acids or bases.

Special emphasis is placed on the applications of buffers in pharmaceutical formulations and biological systems, where maintaining an optimal pH is crucial for drug stability, solubility, and therapeutic effectiveness.

Finally, the unit introduces buffered isotonic solutions, which are used to ensure compatibility with physiological fluids, especially in ophthalmic, parenteral, and nasal preparations. The preparation and importance of maintaining isotonicity in formulations are also discussed to ensure patient comfort and product safety.

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