Micromeritics U-4 Notes

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Micromeritics

  • Micromeritics: Introduction
  • Particle Size and Distribution
  • Mean Particle Size
  • Number and Weight Distribution
  • Particle Number
  • Methods For Determining Particle Size
  • Counting Methods
  • Separation Methods
  • Andreasen Pipette Method
  • Particle Shape
  • Specific Surface Area
  • Methods For Determining Surface Area
  • Derived Properties of Powders
  • Porosity
  • Packing Arrangement
  • Densities of Powders
  • Bulkiness
  • Flow Properties of Powders

Other Units of Physical Pharmaceutics II

Unit 1
Unit 2
Unit 3
Unit 5
Physical Pharmaceutics II

Other Subjects of B Pharmacy 4th Semester

Topic wise notes of:

Medicinal Chemistry I

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Topic wise notes of:

Pharmacognosy & Phytochemistry I

  • Pharmacognosy: Sources, Classification, and Quality Control
  • Conservation and Cultivation of Medicinal Plants
  • Plant tissue culture
  • Role of Pharmacognosy and Secondary Metabolites
  • Drugs of Natural Origin: Plant, Marine, and Primary Metabolites
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Topic wise notes of:

Pharmacology I

  • Introduction to Pharmacology & Pharmacokinetics
  • Pharmacodynamics & Drug Interaction
  • Pharmacology of drugs acting on peripheral nervous system
  • Pharmacology of drugs acting on central nervous system-1
  • Pharmacology of drugs acting on central nervous system-2
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Topic wise notes of:

Pharmaceutical Organic Chemistry III

  • Stereo isomerism
  • Geometrical isomerism
  • Heterocyclic compounds
  • Heterocycles: Synthesis, Reactions & Uses
  • Reactions of synthetic importance
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Micromeritics – Summary

Unit IV covers micromeritics, the science of small particles, which is crucial in pharmaceutical formulation and processing. The unit begins with an explanation of particle size and size distribution, including concepts such as mean particle size, number and weight distribution, and particle number, all of which influence drug dissolution, stability, and bioavailability.

It further details various methods for determining particle size, including counting methods (e.g., microscopy), separation methods (e.g., sieving and sedimentation), and instrumental techniques like laser diffraction. These techniques help in evaluating the consistency and quality of pharmaceutical powders.

The unit also emphasizes particle shape and specific surface area, both of which significantly affect powder flow, compaction, and dissolution. Methods for measuring surface area include permeability techniques and adsorption methods, such as BET (Brunauer–Emmett–Teller) analysis.

Additionally, the unit introduces derived properties of powders, including porosity, packing arrangement, densities (true, bulk, and tapped), and bulkiness. These characteristics are important for optimizing powder formulation, storage, and handling.

Finally, it addresses flow properties of powders, such as angle of repose, compressibility index, and Hausner ratio, which are key to ensuring consistent tablet and capsule production. This unit builds a solid understanding of particle behavior and its impact on pharmaceutical product quality.

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