Anti-TB, UTI & Antiviral Agents Notes [U-3]
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Anti-tubercular Agents
- Tuberculosis (TB)
- Anti-Tubercular Agents
- Classification of Anti-Tubercular Agents
Various Synthetic Anti-Tubercular Agents Drugs
- Isoniazid (INH)*
- Ethionamide
- Ethambutol
- Pyrazinamide
- Para-Aminosalicylic Acid (PASA)
Various Anti-Tubercular Antibiotics Drugs
- Rifampicin
- Rifabutin
- Cycloserine
- Streptomycin
- Capreomycin Sulfate
Urinary tract anti-infective agents
- Urinary Tract Infections (UTIs)
- Urinary Tract Anti-Infective Agents
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Various Quinolones Drug
- Nalidixic Acid
- Norfloxacin
- Enoxacin
- Ciprofloxacin*
- Ofloxacin
- Lomefloxacin
- Sparfloxacin
- Gatifloxacin
- Moxifloxacin
Various Miscellaneous Urinary Tract Anti-Infective Agents Drugs
- Furazolidine
- Nitrofurantoin*
- Methenamine
Antiviral agents
- Antiviral Agents
Various Antiviral Agents (Drugs)
- Amantadine Hydrochloride
- Rimantadine Hydrochloride
- Idoxuridine Trifluoride
- Acyclovir*
- Ganciclovir
- Zidovudine (AZT)
- Didanosine (ddI)
- Zalcitabine (ddC)
- Lamivudine (3TC)
- Loviride
- Delavirdine
- Ribavirin
- Saquinavir
- Indinavir
- Ritonavir
Other Units of Medicinal Chemistry III
Medicinal Chemistry III
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Other Subjects of B Pharmacy 6th Semester
Topic wise notes of:
Biopharmaceutics and Pharmacokinetics
- Biopharmaceutics: Absorption & Distribution
- Drug Elimination, Bioavailability & Bioequivalence
- Pharmacokinetics Models, Dosing & Parameters
- Multicompartment models
- Nonlinear Pharmacokinetics
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Topic wise notes of:
Pharmaceutical Biotechnology
- Introduction to Pharmaceutical Biotechnology
- Genetic Engineering & rDNA Technology
- Immunology and Vaccine Technology
- Microbial Genetics & Biotransformation
- Fermentation & Bioproduct Production
Topic wise notes of:
Pharmaceutical Quality Assurance
- Quality Assurance, GMP, ICH, QbD & Quality System
- GMP: Personnel, Premises & Equipment Control
- Quality Control and Good Laboratory Practice
- Complaints & Document Management
- Calibration and Warehousing
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UNIT–III: Anti-Tubercular, Urinary Tract Anti-Infectives UTI & Antiviral Agents Notes
1. Anti-Tubercular Agents
- Synthetic Agents:
- Isoniazid, Ethionamide, Ethambutol, Pyrazinamide, Para-amino salicylic acid: Inhibit mycobacterial cell wall synthesis or metabolism.
- Antibiotics:
- Rifampicin, Rifabutin: RNA synthesis inhibitors.
- Cycloserine, Streptomycin, Capreomycin sulfate: Inhibit protein or cell wall synthesis.
2. Urinary Tract Anti-Infective Agents
- Quinolones:
- SAR includes substitutions enhancing potency and spectrum.
- Examples: Nalidixic acid, Norfloxacin, Enoxacin, Ciprofloxacin, Ofloxacin, Lomefloxacin, Sparfloxacin, Moxifloxacin.
- Miscellaneous:
- Furazolidine, Nitrofurantoin: Effective in urinary tract infections.
- Methenamine: Releases formaldehyde in acidic urine.
3. Antiviral Agents
- Anti-influenza: Amantadine, Rimantadine.
- Anti-herpes: Idoxuridine, Acyclovir, Ganciclovir.
- Anti-HIV (NRTIs/NNRTIs/Protease Inhibitors):
- Zidovudine, Didanosine, Zalcitabine, Lamivudine, Loviride, Delavirdine.
- Protease Inhibitors: Saquinavir, Indinavir, Ritonavir.
- Others: Ribavirin: Broad-spectrum antiviral
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