Antibiotic & Aminoglycosides Notes [U-1]

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Antibiotics Notes

  • Antibiotics
  • Classification of Antibiotics
  • β-Lactam Antibiotics

Various β-Lactam Antibiotics Drugs

  • Penicillin
  • Cephalosporins
  • β-Lactamase Inhibitors
  • Monobactams (Aztreonam)
  • Aminoglycosides

Various Aminoglycosides Drugs

  • Streptomycin
  • Neomycin
  • Kanamycin
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  • Tetracyclines

Various Tetracyclines Drugs

  • Tetracycline
  • Oxytetracycline
  • Chlortetracycline
  • Minocycline
  • Doxycycline

Other Units of Medicinal Chemistry III

Unit 2
Unit 3
Unit 4
Unit 5
Medicinal Chemistry III
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Other Subjects of B Pharmacy 6th Semester

Herbal Drug Technology

Topic wise notes of:

Herbal Drug Technology

  • Herbal Raw Materials & Indian Medicine Systems
  • Nutraceuticals: Uses, Herbs & Interactions
  • Herbal Cosmetics, Excipients & Formulations
  • Herbal Drug Evaluation, Patents & Regulations
  • Herbal Industry: Scope, GMP & Infrastructure
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Absorption & Distribution

Topic wise notes of:

Biopharmaceutics and Pharmacokinetics

  • Biopharmaceutics: Absorption & Distribution
  • Drug Elimination, Bioavailability & Bioequivalence
  • Pharmacokinetics Models, Dosing & Parameters
  • Multicompartment models
  • Nonlinear Pharmacokinetics
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Pharmacology III Respiratory and GI Tract

Topic wise notes of:

Pharmacology III

  • Respiratory & GI Tract Drug Pharmacology
  • Chemotherapy: Principles & Key Antibiotics
  • Chemotherapy: TB, Fungal & Parasitic Drugs
  • UTIs, Cancer Chemo & Immunopharmacology
  • Toxicology Basics & Chrono pharmacology
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Topic wise notes of:

Pharmaceutical Biotechnology

  • Introduction to Pharmaceutical Biotechnology
  • Genetic Engineering & rDNA Technology
  • Immunology and Vaccine Technology
  • Microbial Genetics & Biotransformation
  • Fermentation & Bioproduct Production
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Pharmaceutical Quality Assurance

Topic wise notes of:

Pharmaceutical Quality Assurance

  • Quality Assurance, GMP, ICH, QbD & Quality System
  • GMP: Personnel, Premises & Equipment Control
  • Quality Control and Good Laboratory Practice
  • Complaints & Document Management
  • Calibration and Warehousing
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UNIT– I: Antibiotics Notes – Summary

  1. Historical Background
    • Antibiotics are substances that inhibit or kill microorganisms.
    • Penicillin, discovered by Alexander Fleming in 1928, was the first widely used antibiotic.
  2. Nomenclature
    • Based on chemical structure, source (natural/semi-synthetic), and microbial target.
    • Includes suffixes like -cillin, -mycin, -cycline.
  3. Stereochemistry
    • Stereochemistry influences binding affinity and biological activity.
    • Specific 3D arrangements are crucial for efficacy and resistance avoidance.
  4. Structure-Activity Relationship (SAR)
    • Modifications in structure can alter potency, spectrum, and resistance profile.
    • SAR guides drug design and improvement.
  5. Chemical Degradation Classification
  6. Important Classes and Products
    • β-Lactam Antibiotics:
      • Penicillin, Cephalosporins, Monobactams, β-Lactamase Inhibitors
    • Aminoglycosides:
      • Streptomycin, Neomycin, Kanamycin
    • Tetracyclines:
      • Tetracycline, Oxytetracycline, Minocycline, Doxycycline

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