Antibiotics & Antimalarials: Structures & SAR Notes [U-2]
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Antibiotics Notes
- Macrolides
Various Macrolides Drugs
- Erythromycin
- Clarithromycin
- Azithromycin
Various Miscellaneous Antibiotics
- Chloramphenicol (SAR & Synthesis included)
- Clindamycin
Prodrugs
- Basic Concept of Prodrugs
Antimalarials
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- Etiology (Causes) of Malaria
- Classification of Antimalarial Drugs
Various Quinolines drugs
- Quinine Sulfate
- Chloroquine*
- Amodiaquine
- Primaquine Phosphate
- Pamaquine*
- Quinacrine Hydrochloride
- Mefloquine
Various Biguanides and Dihydrotriazines Drugs
- Cycloguanil Pamoate
- Proguanil
Various Miscellaneous Antimalarials Drugs
- Pyrimethamine
- Artesunate
- Artemether
- Atovaquone
Other Units of Medicinal Chemistry III
Medicinal Chemistry III
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Other Subjects of B Pharmacy 6th Semester
Topic wise notes of:
Biopharmaceutics and Pharmacokinetics
- Biopharmaceutics: Absorption & Distribution
- Drug Elimination, Bioavailability & Bioequivalence
- Pharmacokinetics Models, Dosing & Parameters
- Multicompartment models
- Nonlinear Pharmacokinetics
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Topic wise notes of:
Pharmaceutical Biotechnology
- Introduction to Pharmaceutical Biotechnology
- Genetic Engineering & rDNA Technology
- Immunology and Vaccine Technology
- Microbial Genetics & Biotransformation
- Fermentation & Bioproduct Production
Topic wise notes of:
Pharmaceutical Quality Assurance
- Quality Assurance, GMP, ICH, QbD & Quality System
- GMP: Personnel, Premises & Equipment Control
- Quality Control and Good Laboratory Practice
- Complaints & Document Management
- Calibration and Warehousing
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Summary of Antibiotics and Antimalarials Notes
1. Antibiotics
- Historical Background: Discovery and evolution of antibiotics; major milestones.
- Nomenclature: Based on source, structure, or microbial target.
- Stereochemistry: Crucial for biological activity and selectivity.
- Structure-Activity Relationship (SAR): Understanding chemical groups essential for activity.
- Chemical Degradation: Hydrolysis, oxidation, and photodegradation pathways.
- Classification & Key Products:
- Chlortetracycline: Tetracycline class; broad-spectrum activity.
- Macrolides:
- Erythromycin: 14-membered ring; bacteriostatic.
- Clarithromycin, Azithromycin: Semi-synthetic derivatives with improved stability.
- Miscellaneous:
- Chloramphenicol: Broad-spectrum; risk of aplastic anemia.
- Clindamycin: Lincosamide; effective against anaerobes.
2. Prodrugs
- Concept: Inactive compounds metabolized into active forms.
- Application: Improve solubility, absorption, and targeted delivery.
3. Antimalarials
- Etiology: Malaria caused by Plasmodium species.
4. Quinolines
- SAR and examples:
- Quinine, Chloroquine, Amodiaquine, Primaquine, Pamaquine, Quinacrine, Mefloquine.
5. Biguanides & Triazines
- Cycloguanil, Proguanil: Inhibit parasite folate pathway.
6. Miscellaneous
- Pyrimethamine, Artesunate, Artemether, Atovaquone: Target various parasite life stages
At FirstHope, we provide BPharm notes that are topic-wise, easy to understand, and designed strictly as per the AKTU and Other Universities, hence designed according to PCI syllabus.
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