Antifungals, Antiprotozoals & Sulfonamides Notes [U-4]
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Antifungal Agents
- Antifungal Agents
Various Antifungal Antibiotics (Drugs)
- Amphotericin B
- Nystatin
- Natamycin
- Griseofulvin
Various Synthetic Antifungal Agents (Drugs)
- Clotrimazole
- Econazole
- Butoconazole
- Oxiconazole
- Tioconazole
- Miconazole*
- Ketoconazole
- Terconazole
- Itraconazole
- Fluconazole
- Naftifine Hydrochloride
- Tolnaftate*
Anti-protozoal Agents
- Protozoa
- Anti-Protozoal Agents
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Various Anti-Protozoal Agents
- Metronidazole*
- Tinidazole
- Ornidazole
- Diloxanide
- Iodoquinol
- Pentamidine Isethionate
- Atovaquone
- Eflornithine
Anthelmintic
- Anthelmintic Agents
Various Anthelmintic Agents
- Diethylcarbamazine Citrate (DEC)*
- Thiabendazole
- Mebendazole (MBZ)*
- Albendazole
- Niclosamide
- Oxamniquine
- Praziquantel
- Ivermectin
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Sulphonamides
- Sulfonamides and Sulfones
Various Sulfonamides
- Sulfamethizole
- Sulfisoxazole
- Sulfapyridine
- Sulfamethizine
- Sulfacetamide*
- Sulphapyridine
- Sulfamethoxazole*
- Sulphadiazine
- Mefenide Acetate
- Sulfasalazine
Folate Reductase Inhibitors
- Trimethoprim*
- Cotrimoxazole
Various Sulfones
- Dapsone*
Other Units of Medicinal Chemistry III
Medicinal Chemistry III
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Other Subjects of B Pharmacy 6th Semester
Topic wise notes of:
Biopharmaceutics and Pharmacokinetics
- Biopharmaceutics: Absorption & Distribution
- Drug Elimination, Bioavailability & Bioequivalence
- Pharmacokinetics Models, Dosing & Parameters
- Multicompartment models
- Nonlinear Pharmacokinetics
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Topic wise notes of:
Pharmaceutical Biotechnology
- Introduction to Pharmaceutical Biotechnology
- Genetic Engineering & rDNA Technology
- Immunology and Vaccine Technology
- Microbial Genetics & Biotransformation
- Fermentation & Bioproduct Production
Topic wise notes of:
Pharmaceutical Quality Assurance
- Quality Assurance, GMP, ICH, QbD & Quality System
- GMP: Personnel, Premises & Equipment Control
- Quality Control and Good Laboratory Practice
- Complaints & Document Management
- Calibration and Warehousing
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UNIT–IV: Antifungal, Anti-protozoal, Anthelmintic Agents & Sulfonamides Notes
1. Antifungal Agents
- Antifungal Antibiotics:
- Amphotericin-B, Nystatin, Natamycin, Griseofulvin: Disrupt fungal cell membrane or mitosis.
- Synthetic Antifungals:
- Azoles: Clotrimazole, Econazole, Miconazole, Ketoconazole, Fluconazole, Itraconazole, etc.
- Others: Naftifine HCl, Tolnaftate: Used topically for dermatophytes.
2. Anti-protozoal Agents
- Treat amoebiasis, trichomoniasis, and leishmaniasis.
- Metronidazole, Tinidazole, Ornidazole: Nitroimidazoles.
- Others: Diloxanide, Iodoquinol, Pentamidine, Atovaquone, Eflornithine.
3. Anthelmintics
- Used against intestinal and systemic helminths.
- Diethylcarbamazine, Mebendazole, Albendazole, Ivermectin, Niclosamide, Praziquantel.
4. Sulfonamides and Sulfones
- Historical Background & SAR: First antimicrobial class; mimic PABA to inhibit folate synthesis.
- Examples:
- Sulfamethizole, Sulfisoxazole, Sulfamethoxazole, Sulphadiazine, Sulphacetamide, Sulfasalazine.
- Folate Reductase Inhibitors:
- Trimethoprim, Cotrimoxazole (synergistic combination).
- Sulfones:
- Dapsone: Used in leprosy and dermatitis herpetiformis
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