Intro to Drug Design & QSAR Approaches Notes [U-5]

Buy Premium

Get The High-Quality Pdf Notes on App

Advertisements

Introduction to Drug Design

  • Introduction to Drug Design
  • Various Approaches Used in Drug Design
  • Physicochemical Parameters Used in QSAR
  • Pharmacophore Modeling
  • Molecular Docking Techniques

Combinatorial Chemistry

  • Combinatorial Chemistry: Concept and Application

Combinatorial Chemistry: Synthesis Methods

  • Solid-Phase Combinatorial Chemistry
  • Solution-Phase Synthesis in Combinatorial Chemistry
Advertisements

Other Units of Medicinal Chemistry III

Unit 1
Unit 2
Unit 3
Unit 4
Medicinal Chemistry III
Advertisements

Other Subjects of B Pharmacy 6th Semester

Herbal Drug Technology

Topic wise notes of:

Herbal Drug Technology

  • Herbal Raw Materials & Indian Medicine Systems
  • Nutraceuticals: Uses, Herbs & Interactions
  • Herbal Cosmetics, Excipients & Formulations
  • Herbal Drug Evaluation, Patents & Regulations
  • Herbal Industry: Scope, GMP & Infrastructure
Select
Absorption & Distribution

Topic wise notes of:

Biopharmaceutics and Pharmacokinetics

  • Biopharmaceutics: Absorption & Distribution
  • Drug Elimination, Bioavailability & Bioequivalence
  • Pharmacokinetics Models, Dosing & Parameters
  • Multicompartment models
  • Nonlinear Pharmacokinetics
Select
Advertisements
Pharmacology III Respiratory and GI Tract

Topic wise notes of:

Pharmacology III

  • Respiratory & GI Tract Drug Pharmacology
  • Chemotherapy: Principles & Key Antibiotics
  • Chemotherapy: TB, Fungal & Parasitic Drugs
  • UTIs, Cancer Chemo & Immunopharmacology
  • Toxicology Basics & Chrono pharmacology
Select

Topic wise notes of:

Pharmaceutical Biotechnology

  • Introduction to Pharmaceutical Biotechnology
  • Genetic Engineering & rDNA Technology
  • Immunology and Vaccine Technology
  • Microbial Genetics & Biotransformation
  • Fermentation & Bioproduct Production
Select
Pharmaceutical Quality Assurance

Topic wise notes of:

Pharmaceutical Quality Assurance

  • Quality Assurance, GMP, ICH, QbD & Quality System
  • GMP: Personnel, Premises & Equipment Control
  • Quality Control and Good Laboratory Practice
  • Complaints & Document Management
  • Calibration and Warehousing
Select
Advertisements

UNIT–V: Intro to Drug Design and Related Concepts Notes

1. Drug Design

  • Involves designing molecules with desired biological activity.
  • Approaches: Structure-based, ligand-based, and prodrug strategies.

2. QSAR (Quantitative Structure–Activity Relationship)

  • Links chemical structure to biological activity.
  • Key Parameters:
    • Log P (lipophilicity)
    • Hammett’s σ (electronic effects)
    • Taft’s Es (steric effects)
    • Hansch Analysis (multivariate approach)

3. Pharmacophore Modeling & Docking

  • Pharmacophore: Key features needed for activity.
  • Docking: Predicts drug binding to targets.

4. Combinatorial Chemistry

  • Used to create diverse compound libraries.
  • Methods: Solid-phase and solution-phase synthesis

At FirstHope, we provide BPharm notes that are topic-wise, easy to understand, and designed strictly as per the AKTU and Other Universities, hence designed according to PCI syllabus.

Advertisements

Thank you for reading from Firsthope's notes, don't forget to check YouTube videos!