Intro to Drug Design & QSAR Approaches Notes [U-5]

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Introduction to Drug Design

  • Introduction to Drug Design
  • Various Approaches Used in Drug Design
  • Physicochemical Parameters Used in QSAR
  • Pharmacophore Modeling
  • Molecular Docking Techniques

Combinatorial Chemistry

  • Combinatorial Chemistry: Concept and Application

Combinatorial Chemistry: Synthesis Methods

  • Solid-Phase Combinatorial Chemistry
  • Solution-Phase Synthesis in Combinatorial Chemistry
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Other Units of Medicinal Chemistry III

Unit 1
Unit 2
Unit 3
Unit 4
Medicinal Chemistry III
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Other Subjects of B Pharmacy 6th Semester

Herbal Drug Technology

Topic wise notes of:

Herbal Drug Technology

  • Herbal Raw Materials & Indian Medicine Systems
  • Nutraceuticals: Uses, Herbs & Interactions
  • Herbal Cosmetics, Excipients & Formulations
  • Herbal Drug Evaluation, Patents & Regulations
  • Herbal Industry: Scope, GMP & Infrastructure
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Absorption & Distribution

Topic wise notes of:

Biopharmaceutics and Pharmacokinetics

  • Biopharmaceutics: Absorption & Distribution
  • Drug Elimination, Bioavailability & Bioequivalence
  • Pharmacokinetics Models, Dosing & Parameters
  • Multicompartment models
  • Nonlinear Pharmacokinetics
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Pharmacology III Respiratory and GI Tract

Topic wise notes of:

Pharmacology III

  • Respiratory & GI Tract Drug Pharmacology
  • Chemotherapy: Principles & Key Antibiotics
  • Chemotherapy: TB, Fungal & Parasitic Drugs
  • UTIs, Cancer Chemo & Immunopharmacology
  • Toxicology Basics & Chrono pharmacology
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Topic wise notes of:

Pharmaceutical Biotechnology

  • Introduction to Pharmaceutical Biotechnology
  • Genetic Engineering & rDNA Technology
  • Immunology and Vaccine Technology
  • Microbial Genetics & Biotransformation
  • Fermentation & Bioproduct Production
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Pharmaceutical Quality Assurance

Topic wise notes of:

Pharmaceutical Quality Assurance

  • Quality Assurance, GMP, ICH, QbD & Quality System
  • GMP: Personnel, Premises & Equipment Control
  • Quality Control and Good Laboratory Practice
  • Complaints & Document Management
  • Calibration and Warehousing
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UNIT–V: Intro to Drug Design and Related Concepts Notes

1. Drug Design

  • Involves designing molecules with desired biological activity.
  • Approaches: Structure-based, ligand-based, and prodrug strategies.

2. QSAR (Quantitative Structure–Activity Relationship)

  • Links chemical structure to biological activity.
  • Key Parameters:
    • Log P (lipophilicity)
    • Hammett’s σ (electronic effects)
    • Taft’s Es (steric effects)
    • Hansch Analysis (multivariate approach)

3. Pharmacophore Modeling & Docking

  • Pharmacophore: Key features needed for activity.
  • Docking: Predicts drug binding to targets.

4. Combinatorial Chemistry

  • Used to create diverse compound libraries.
  • Methods: Solid-phase and solution-phase synthesis

At FirstHope, we provide BPharm notes that are topic-wise, easy to understand, and designed strictly as per the AKTU and Other Universities, hence designed according to PCI syllabus.

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