Chemotherapy: TB, Fungal & Parasitic Drugs Notes [U-3]

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Chemotherapy

  • General Principles of Chemotherapy
  • Sulfonamides (Sulfa Drugs)
  • Cotrimoxazole (Trimethoprim + Sulfamethoxazole)

Antibiotics

  • Penicillins
  • Cephalosporins
  • Macrolides
  • Quinolones and Fluoroquinolones
  • Tetracyclines
  • Aminoglycosides
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Other Units of Pharmaceutical Quality Assurance

Unit 1
Unit 2
Unit 4
Unit 5
Pharmacology III
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Other Subjects of B Pharmacy 6th Semester

Herbal Drug Technology

Topic wise notes of:

Herbal Drug Technology

  • Herbal Raw Materials & Indian Medicine Systems
  • Nutraceuticals: Uses, Herbs & Interactions
  • Herbal Cosmetics, Excipients & Formulations
  • Herbal Drug Evaluation, Patents & Regulations
  • Herbal Industry: Scope, GMP & Infrastructure
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Absorption & Distribution

Topic wise notes of:

Biopharmaceutics and Pharmacokinetics

  • Biopharmaceutics: Absorption & Distribution
  • Drug Elimination, Bioavailability & Bioequivalence
  • Pharmacokinetics Models, Dosing & Parameters
  • Multicompartment models
  • Nonlinear Pharmacokinetics
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Pharmaceutical Quality Assurance

Topic wise notes of:

Pharmaceutical Quality Assurance

  • Quality Assurance, GMP, ICH, QbD & Quality System
  • GMP: Personnel, Premises & Equipment Control
  • Quality Control and Good Laboratory Practice
  • Complaints & Document Management
  • Calibration and Warehousing
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Antibiotics & Aminoglycosides in Medicinal Chemistry III

Topic wise notes of:

Medicinal Chemistry III

  • Antibiotics & Aminoglycosides
  • Antibiotics & Antimalarials: Structures & SAR
  • Anti-TB, UTI & Antiviral Agents
  • Antifungals, Antiprotozoals & Sulfonamides
  • Intro to Drug Design & QSAR Approaches
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Pharmaceutical Biotechnology

Topic wise notes of:

Pharmaceutical Biotechnology

  • Introduction to Pharmaceutical Biotechnology
  • Genetic Engineering & rDNA Technology
  • Immunology and Vaccine Technology
  • Microbial Genetics & Biotransformation
  • Fermentation & Bioproduct Production
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Chemotherapy Drugs Summary

a. Antitubercular Agents

  • Used to treat tuberculosis.
  • Common drugs: Isoniazid, Rifampicin, Pyrazinamide, Ethambutol.
  • Aim: inhibit cell wall synthesis or RNA transcription in Mycobacterium tuberculosis.

b. Antileprotic Agents

  • Target Mycobacterium leprae.
  • Key drugs: Dapsone, Clofazimine, Rifampicin.
  • Therapy often combined to prevent resistance.

c. Antifungal Agents

  • Act against fungal infections.
  • Examples: Amphotericin B, Azoles (ketoconazole, fluconazole).
  • Mechanism: disrupt cell membrane ergosterol.

d. Antiviral Drugs

  • Block viral replication.
  • Examples: Acyclovir (herpes), Zidovudine (HIV), Oseltamivir (influenza).

e. Anthelmintics

  • Kill or paralyze parasitic worms.
  • Examples: Albendazole, Mebendazole, Ivermectin.

f. Antimalarial Drugs

  • Target Plasmodium species.
  • Drugs: Chloroquine, Artemisinin derivatives, Primaquine.

g. Antiamoebic Agents

  • Used for amoebiasis caused by Entamoeba histolytica.
  • Drugs: Metronidazole, Tinidazole.
  • Act by damaging DNA of parasites.

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