Chemotherapy: TB, Fungal & Parasitic Drugs Notes [U-3]
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Chemotherapy
- General Principles of Chemotherapy
- Sulfonamides (Sulfa Drugs)
- Cotrimoxazole (Trimethoprim + Sulfamethoxazole)
Antibiotics
- Penicillins
- Cephalosporins
- Macrolides
- Quinolones and Fluoroquinolones
- Tetracyclines
- Aminoglycosides
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Other Units of Pharmaceutical Quality Assurance
Pharmacology III
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Other Subjects of B Pharmacy 6th Semester
Topic wise notes of:
Biopharmaceutics and Pharmacokinetics
- Biopharmaceutics: Absorption & Distribution
- Drug Elimination, Bioavailability & Bioequivalence
- Pharmacokinetics Models, Dosing & Parameters
- Multicompartment models
- Nonlinear Pharmacokinetics
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Topic wise notes of:
Pharmaceutical Quality Assurance
- Quality Assurance, GMP, ICH, QbD & Quality System
- GMP: Personnel, Premises & Equipment Control
- Quality Control and Good Laboratory Practice
- Complaints & Document Management
- Calibration and Warehousing
Topic wise notes of:
Medicinal Chemistry III
- Antibiotics & Aminoglycosides
- Antibiotics & Antimalarials: Structures & SAR
- Anti-TB, UTI & Antiviral Agents
- Antifungals, Antiprotozoals & Sulfonamides
- Intro to Drug Design & QSAR Approaches
Topic wise notes of:
Pharmaceutical Biotechnology
- Introduction to Pharmaceutical Biotechnology
- Genetic Engineering & rDNA Technology
- Immunology and Vaccine Technology
- Microbial Genetics & Biotransformation
- Fermentation & Bioproduct Production
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Chemotherapy Drugs Summary
a. Antitubercular Agents
- Used to treat tuberculosis.
- Common drugs: Isoniazid, Rifampicin, Pyrazinamide, Ethambutol.
- Aim: inhibit cell wall synthesis or RNA transcription in Mycobacterium tuberculosis.
b. Antileprotic Agents
- Target Mycobacterium leprae.
- Key drugs: Dapsone, Clofazimine, Rifampicin.
- Therapy often combined to prevent resistance.
c. Antifungal Agents
- Act against fungal infections.
- Examples: Amphotericin B, Azoles (ketoconazole, fluconazole).
- Mechanism: disrupt cell membrane ergosterol.
d. Antiviral Drugs
- Block viral replication.
- Examples: Acyclovir (herpes), Zidovudine (HIV), Oseltamivir (influenza).
e. Anthelmintics
- Kill or paralyze parasitic worms.
- Examples: Albendazole, Mebendazole, Ivermectin.
f. Antimalarial Drugs
- Target Plasmodium species.
- Drugs: Chloroquine, Artemisinin derivatives, Primaquine.
g. Antiamoebic Agents
- Used for amoebiasis caused by Entamoeba histolytica.
- Drugs: Metronidazole, Tinidazole.
- Act by damaging DNA of parasites.
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