Toxicology Basics & Chrono pharmacology Notes [U-5]

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Principles of toxicology

  • Principles of Toxicology
  • Acute toxicity
  • Subacute toxicity
  • Chronic Toxicity
  • Genotoxicity
  • Carcinogenicity
  • Teratogenicity
  • Mutagenicity
  • General principles of treatment of poisoning

Clinical Symptoms and Management of Specific Poisonings

  • Barbiturates Poisoning
  • Morphine (Opioid) Poisoning
  • Organophosphorus (OP) Compound Poisoning

Heavy Metals Poisoning: Lead, Mercury, and Arsenic

  • Lead Poisoning
  • Mercury Poisoning
  • Arsenic Poisoning

Chrono pharmacology

  • Chronopharmacology
  • Rhythms and Cycles in Chronopharmacology
  • Biological Clock and Its Significance
  • Chronotherapy
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Other Units of Pharmaceutical Quality Assurance

Unit 1
Unit 2
Unit 3
Unit 4
Pharmacology III
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Other Subjects of B Pharmacy 6th Semester

Herbal Drug Technology

Topic wise notes of:

Herbal Drug Technology

  • Herbal Raw Materials & Indian Medicine Systems
  • Nutraceuticals: Uses, Herbs & Interactions
  • Herbal Cosmetics, Excipients & Formulations
  • Herbal Drug Evaluation, Patents & Regulations
  • Herbal Industry: Scope, GMP & Infrastructure
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Absorption & Distribution

Topic wise notes of:

Biopharmaceutics and Pharmacokinetics

  • Biopharmaceutics: Absorption & Distribution
  • Drug Elimination, Bioavailability & Bioequivalence
  • Pharmacokinetics Models, Dosing & Parameters
  • Multicompartment models
  • Nonlinear Pharmacokinetics
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Pharmaceutical Quality Assurance

Topic wise notes of:

Pharmaceutical Quality Assurance

  • Quality Assurance, GMP, ICH, QbD & Quality System
  • GMP: Personnel, Premises & Equipment Control
  • Quality Control and Good Laboratory Practice
  • Complaints & Document Management
  • Calibration and Warehousing
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Antibiotics & Aminoglycosides in Medicinal Chemistry III

Topic wise notes of:

Medicinal Chemistry III

  • Antibiotics & Aminoglycosides
  • Antibiotics & Antimalarials: Structures & SAR
  • Anti-TB, UTI & Antiviral Agents
  • Antifungals, Antiprotozoals & Sulfonamides
  • Intro to Drug Design & QSAR Approaches
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Pharmaceutical Biotechnology

Topic wise notes of:

Pharmaceutical Biotechnology

  • Introduction to Pharmaceutical Biotechnology
  • Genetic Engineering & rDNA Technology
  • Immunology and Vaccine Technology
  • Microbial Genetics & Biotransformation
  • Fermentation & Bioproduct Production
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Toxicology Notes Summary

  • Toxicity types:
    • Acute: Single/short exposure.
    • Subacute: Repeated weeks.
    • Chronic: Long-term low dose.
  • Special toxicities:
    • Genotoxicity (DNA damage), Carcinogenicity (cancer), Teratogenicity (birth defects), Mutagenicity (gene changes).
  • Treatment principles: Prevent absorption, enhance elimination, use antidotes, supportive care.
  • Specific poisons:
    • Barbiturates → CNS depression; alkaline diuresis.
    • Morphine → Naloxone.
    • Organophosphates → Atropine, Pralidoxime.
    • Lead, Mercury, Arsenic → Chelation therapy.

Chrono pharmacology Notes Summary

  • Rhythms: Circadian, ultradian, infradian cycles.
  • Biological clock: Regulates physiology and drug response.
  • Chronotherapy: Time-based drug dosing for better efficacy and lower toxicity.

At FirstHope, we provide BPharm notes that are topic-wise, easy to understand, and designed strictly as per the AKTU and Other Universities, hence designed according to PCI syllabus.

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