Biopharmaceutics: Absorption & Distribution Notes [U-1]
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Introduction to Biopharmaceutics and Absorption
- Introduction to Biopharmaceutics
- Mechanisms of Drug Absorption Through the Gastrointestinal Tract (GIT)
- Factors Influencing Drug Absorption Through the Gastrointestinal Tract (GIT)
- Absorption of drug from Non per-oral extra-vascular routes
Distribution
- Drug Distribution in Biopharmaceutics
- Physiological Properties Affecting Drug Distribution
- Physiological Barriers to Drug Distribution
- Tissue Permeability of Drugs
- Binding of Drugs
- Apparent Volume of Distribution (Vd)
- Plasma Protein Binding of Drugs
- Tissue Protein Binding of Drugs
- Factors Affecting Protein-Drug Binding
- Kinetics of Protein Binding
- Clinical significance of protein binding of drugs
Other Units of Biopharmaceutics and Pharmacokinetics
Biopharmaceutics and Pharmacokinetics
Other Subjects of B Pharmacy 6th Semester
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- Quality Assurance, GMP, ICH, QbD & Quality System
- GMP: Personnel, Premises & Equipment Control
- Quality Control and Good Laboratory Practice
- Complaints & Document Management
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Unit-I: Introduction to Biopharmaceutics: Absorption & Distribution
This unit introduces the fundamental concepts of biopharmaceutics, focusing on the journey of drugs through the body, particularly concerning absorption, distribution, and protein binding.
1. Drug Absorption
- Mechanisms through GIT: Includes passive diffusion, facilitated diffusion, active transport, and endocytosis.
- Factors Influencing GIT Absorption: Drug solubility, pH, gastric emptying time, intestinal motility, and presence of food or enzymes.
- Non-Oral Extravascular Routes: Covers drug absorption via routes like intramuscular, subcutaneous, and transdermal pathways, each with unique absorption profiles.
2. Drug Distribution
- Tissue Permeability: Depends on drug properties (lipophilicity, ionization) and tissue characteristics (blood flow, membrane permeability).
- Binding of Drugs: Involves reversible interaction with plasma and tissue proteins, affecting free drug concentration and efficacy.
- Volume of Distribution (Vd): A theoretical value indicating the extent of drug distribution in body tissues.
3. Protein-Drug Binding
- Plasma and Tissue Binding: Influences drug activity, duration, and elimination.
- Factors Affecting Binding: Include drug concentration, protein levels, and affinity.
- Kinetics and Clinical Significance: Binding dynamics impact drug dosing, potential drug interactions, and therapeutic effectiveness.
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