Drug Elimination, Bioavailability & Bioequivalence Notes [U-2]

Buy Premium

Get The High-Quality Pdf Notes on App

Elimination

  • Drug Metabolism (Biotransformation)
  • Renal Excretion of Drugs
  • Factors Affecting Renal Excretion of Drugs
  • Renal Clearance (Clᵣ)
  • Non renal routes of drug excretion of drug

Bioavailability and Bioequivalence

  • Bioavailability (BA): Definition and Objectives
  • Absolute and Relative Bioavailability
  • Measurement of Bioavailability
  • In-vitro drug dissolution models
  • In-Vitro-In-Vivo Correlation (IVIVC)
  • Bioequivalence Studies
  • Methods to Enhance the Dissolution Rates and Bioavailability of Poorly Soluble Drugs

Other Units of Biopharmaceutics and Pharmacokinetics

Unit 1
Unit 3
Unit 4
Unit 5
Biopharmaceutics and Pharmacokinetics

Other Subjects of B Pharmacy 6th Semester

Medicinal Chemistry III

Topic wise notes of:

Medicinal Chemistry III

  • Antibiotics & Aminoglycosides
  • Antibiotics & Antimalarials: Structures & SAR
  • Anti-TB, UTI & Antiviral Agents
  • Antifungals, Antiprotozoals & Sulfonamides
  • Intro to Drug Design & QSAR Approaches
Select
Herbal Drug Technology

Topic wise notes of:

Herbal Drug Technology

  • Herbal Raw Materials & Indian Medicine Systems
  • Nutraceuticals: Uses, Herbs & Interactions
  • Herbal Cosmetics, Excipients & Formulations
  • Herbal Drug Evaluation, Patents & Regulations
  • Herbal Industry: Scope, GMP & Infrastructure
Select
Pharmacology III Respiratory and GI Tract

Topic wise notes of:

Pharmacology III

  • Respiratory & GI Tract Drug Pharmacology
  • Chemotherapy: Principles & Key Antibiotics
  • Chemotherapy: TB, Fungal & Parasitic Drugs
  • UTIs, Cancer Chemo & Immunopharmacology
  • Toxicology Basics & Chrono pharmacology
Select

Topic wise notes of:

Pharmaceutical Biotechnology

  • Introduction to Pharmaceutical Biotechnology
  • Genetic Engineering & rDNA Technology
  • Immunology and Vaccine Technology
  • Microbial Genetics & Biotransformation
  • Fermentation & Bioproduct Production
Select
Pharmaceutical Quality Assurance

Topic wise notes of:

Pharmaceutical Quality Assurance

  • Quality Assurance, GMP, ICH, QbD & Quality System
  • GMP: Personnel, Premises & Equipment Control
  • Quality Control and Good Laboratory Practice
  • Complaints & Document Management
  • Calibration and Warehousing
Select

Unit-I: Drug Elimination, Bioavailability, and Bioequivalence Notes Summary

This section covers key aspects of drug elimination and the principles of bioavailability and bioequivalence.

1. Drug Elimination

  • Metabolism: Focuses on the biotransformation of drugs, primarily in the liver, through Phase I (oxidation, reduction, hydrolysis) and Phase II (conjugation) metabolic pathways.
  • Renal Excretion: Involves filtration, secretion, and reabsorption in the kidneys.
  • Factors Affecting Renal Excretion: Includes age, renal function, drug properties, and plasma protein binding.
  • Renal Clearance: A quantitative measure of the efficiency of renal drug elimination.
  • Non-Renal Excretion: Includes pulmonary, biliary, salivary, and sweat excretion routes.

2. Bioavailability and Bioequivalence

  • Definitions and Objectives: Bioavailability refers to the rate and extent of drug absorption. Bioequivalence ensures therapeutic equivalence between drug products.
  • Types: Absolute (comparison to IV route) and relative (comparison between oral formulations).
  • Measurement Techniques: Include plasma drug concentration profiles and urinary excretion data.
  • In-vitro Models and IVIVC: Drug dissolution testing and in-vitro-in-vivo correlations predict absorption.
  • Enhancement Strategies: Use of solubilizers, particle size reduction, and formulation techniques to improve dissolution and bioavailability of poorly soluble drugs.

At FirstHope, we provide BPharm notes that are topic-wise, easy to understand, and designed strictly as per the AKTU and Other Universities, hence designed according to PCI syllabus.

Thank you for reading from Firsthope's notes, don't forget to check YouTube videos!