Multicompartment Models Notes [U-4]

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Multicompartment models

  • Multicompartment Models in Pharmacokinetics
  • Two-Compartment Open Model
  • Two Compartment Open Model – IV Bolus
  • Kinetics of Multiple Dosing
  • Steady-State Drug Levels
  • Calculation of Loading and Maintenance Doses
  • Significance of Loading and Maintenance Dose Calculations in Clinical Settings

Other Units of Biopharmaceutics and Pharmacokinetics

Unit 1
Unit 2
Unit 3
Unit 5
Biopharmaceutics and Pharmacokinetics

Other Subjects of B Pharmacy 6th Semester

Medicinal Chemistry III

Topic wise notes of:

Medicinal Chemistry III

  • Antibiotics & Aminoglycosides
  • Antibiotics & Antimalarials: Structures & SAR
  • Anti-TB, UTI & Antiviral Agents
  • Antifungals, Antiprotozoals & Sulfonamides
  • Intro to Drug Design & QSAR Approaches
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Herbal Drug Technology

Topic wise notes of:

Herbal Drug Technology

  • Herbal Raw Materials & Indian Medicine Systems
  • Nutraceuticals: Uses, Herbs & Interactions
  • Herbal Cosmetics, Excipients & Formulations
  • Herbal Drug Evaluation, Patents & Regulations
  • Herbal Industry: Scope, GMP & Infrastructure
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Pharmacology III Respiratory and GI Tract

Topic wise notes of:

Pharmacology III

  • Respiratory & GI Tract Drug Pharmacology
  • Chemotherapy: Principles & Key Antibiotics
  • Chemotherapy: TB, Fungal & Parasitic Drugs
  • UTIs, Cancer Chemo & Immunopharmacology
  • Toxicology Basics & Chrono pharmacology
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Pharmaceutical Biotechnology

Topic wise notes of:

Pharmaceutical Biotechnology

  • Introduction to Pharmaceutical Biotechnology
  • Genetic Engineering & rDNA Technology
  • Immunology and Vaccine Technology
  • Microbial Genetics & Biotransformation
  • Fermentation & Bioproduct Production
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Pharmaceutical Quality Assurance

Topic wise notes of:

Pharmaceutical Quality Assurance

  • Quality Assurance, GMP, ICH, QbD & Quality System
  • GMP: Personnel, Premises & Equipment Control
  • Quality Control and Good Laboratory Practice
  • Complaints & Document Management
  • Calibration and Warehousing
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Unit-IV: Multicompartment Models and Multiple Dosing Notes Summary

This unit covers advanced pharmacokinetics, focusing on drug distribution and dosing strategies.

1. Two-Compartment Model (IV Bolus):

Describes drug movement between central and peripheral compartments with distinct distribution and elimination phases.

2. Multiple Dosing Kinetics:
Explains how repeated dosing leads to drug accumulation and how dosing intervals affect plasma concentration.

3. Steady-State Levels:
Achieved when drug input equals elimination; important for maintaining consistent therapeutic effect.

4. Dose Calculations:
Covers loading dose for rapid effect and maintenance dose for sustained levels—essential for effective and safe therapy

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