Nonlinear Pharmacokinetics Notes [U-5]
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Nonlinear Pharmacokinetics
- Introduction to Nonlinear Pharmacokinetics
- Factors Causing Nonlinear Pharmacokinetics
- Michaelis Menten equation
- Michaelis-Menten Parameter Estimation Methods
Other Units of Biopharmaceutics and Pharmacokinetics
Biopharmaceutics and Pharmacokinetics
Other Subjects of B Pharmacy 6th Semester
Topic wise notes of:
Medicinal Chemistry III
- Antibiotics & Aminoglycosides
- Antibiotics & Antimalarials: Structures & SAR
- Anti-TB, UTI & Antiviral Agents
- Antifungals, Antiprotozoals & Sulfonamides
- Intro to Drug Design & QSAR Approaches
Topic wise notes of:
Pharmaceutical Biotechnology
- Introduction to Pharmaceutical Biotechnology
- Genetic Engineering & rDNA Technology
- Immunology and Vaccine Technology
- Microbial Genetics & Biotransformation
- Fermentation & Bioproduct Production
Topic wise notes of:
Pharmaceutical Quality Assurance
- Quality Assurance, GMP, ICH, QbD & Quality System
- GMP: Personnel, Premises & Equipment Control
- Quality Control and Good Laboratory Practice
- Complaints & Document Management
- Calibration and Warehousing
Unit-V: Nonlinear Pharmacokinetics Notes Summary
This unit introduces the concept of nonlinear pharmacokinetics, where drug kinetics do not follow first-order behavior.
1. Introduction:
Nonlinear pharmacokinetics occurs when drug absorption, distribution, metabolism, or excretion processes become saturated.
2. Causes of Non-Linearity:
Includes enzyme saturation, protein binding limitations, active transport, and changes in hepatic or renal function.
3. Michaelis-Menten Method:
A mathematical model used to estimate nonlinear parameters (Vmax and Km), describing how drug concentration affects rate of metabolism.
4. Examples:
Drugs like phenytoin and ethanol exhibit nonlinear kinetics, requiring careful dose adjustment to avoid toxicity
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