Pharmacokinetics Models, Dosing & Parameters Notes [U-3]

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Pharmacokinetics

  • Pharmacokinetics: Definition and Introduction
  • Plasma Drug Concentration-Time Profile
  • Reaction Kinetics: Rate, Rate Constants, and Order
  • Compartmental Models in Pharmacokinetics
  • Non-Compartment Models (Model-Independent Approach)
  • Physiological Models (PBPK – Physiologically Based Pharmacokinetic Models)
  • One-Compartment Open Model
  • One-Compartment Model with Intravenous Bolus Administration
  • One-Compartment Model with Intravenous Infusion
  • One-Compartment Model with Extravascular Administration

Pharmacokinetics parameters

  • Pharmacokinetic Parameters
  • Methods of Drug Elimination

Other Units of Biopharmaceutics and Pharmacokinetics

Unit 1
Unit 2
Unit 4
Unit 5
Biopharmaceutics and Pharmacokinetics

Other Subjects of B Pharmacy 6th Semester

Medicinal Chemistry III

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Medicinal Chemistry III

  • Antibiotics & Aminoglycosides
  • Antibiotics & Antimalarials: Structures & SAR
  • Anti-TB, UTI & Antiviral Agents
  • Antifungals, Antiprotozoals & Sulfonamides
  • Intro to Drug Design & QSAR Approaches
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Herbal Drug Technology

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Herbal Drug Technology

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  • Nutraceuticals: Uses, Herbs & Interactions
  • Herbal Cosmetics, Excipients & Formulations
  • Herbal Drug Evaluation, Patents & Regulations
  • Herbal Industry: Scope, GMP & Infrastructure
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Pharmacology III Respiratory and GI Tract

Topic wise notes of:

Pharmacology III

  • Respiratory & GI Tract Drug Pharmacology
  • Chemotherapy: Principles & Key Antibiotics
  • Chemotherapy: TB, Fungal & Parasitic Drugs
  • UTIs, Cancer Chemo & Immunopharmacology
  • Toxicology Basics & Chrono pharmacology
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Pharmaceutical Biotechnology

Topic wise notes of:

Pharmaceutical Biotechnology

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Pharmaceutical Quality Assurance

Topic wise notes of:

Pharmaceutical Quality Assurance

  • Quality Assurance, GMP, ICH, QbD & Quality System
  • GMP: Personnel, Premises & Equipment Control
  • Quality Control and Good Laboratory Practice
  • Complaints & Document Management
  • Calibration and Warehousing
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Unit-III: Pharmacokinetics Models Dosing & Parameters Notes

This unit provides an overview of pharmacokinetics, focusing on drug movement through the body using various models and key parameters.

1. Introduction to Pharmacokinetics

  • Definition: The quantitative study of drug absorption, distribution, metabolism, and excretion (ADME).
  • Models Used:
    • Compartment Models: Simplified representations like one-compartment or multi-compartment systems.
    • Non-Compartment Models: Model-independent methods based on statistical moment theory.
    • Physiological Models: Based on actual anatomical and physiological parameters of organs and tissues.

2. One-Compartment Open Model

  • Intravenous Injection (Bolus): Immediate input of drug into systemic circulation.
  • Intravenous Infusion: Continuous drug administration at a constant rate.
  • Extravascular Administration: Includes oral, intramuscular, and subcutaneous routes where absorption phase is involved.

3. Pharmacokinetic Parameters

  • Kel (Elimination Rate Constant)
  • CL (Clearance)
  • t½ (Half-life)
  • Vd (Volume of Distribution)
  • AUC (Area Under the Curve)
  • Ka (Absorption Rate Constant)
  • Clt (Total Clearance)

4. Significance and Applications

These parameters help in determining dosing regimens, evaluating drug efficacy and safety, and designing drug delivery systems

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