Buclizine Hydrochloride is an H₁-antihistamine with anticholinergic and antiemetic properties, commonly used for managing motion sickness and vertigo. Its chemical structure features a piperazine ring attached to a diphenylmethyl group with an ethyl substituent, and its hydrochloride form enhances solubility. By blocking H₁ receptors and reducing histamine effects, Buclizine effectively controls symptoms such as nausea, vomiting, and dizziness.
Structure of Buclizine Hydrochloride
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- Buclizine contains a piperazine ring bonded to a diphenylmethyl group with an ethyl substituent. The hydrochloride salt improves solubility.
- Chemical Formula: C₂₁H₂₈ClN₃·HCl
Mode of Action
- Acts as an H₁-receptor antagonist with anticholinergic and antiemetic properties.
- It reduces histamine-induced symptoms and prevents nausea.
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Uses
- Motion Sickness: Prevents and treats nausea and vomiting related to travel.
- Vertigo: Provides relief from dizziness associated with vestibular disorders.
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