Chlorcyclizine Hydrochloride is a first-generation H₁-antihistamine primarily indicated for allergic conditions and motion sickness. Structurally, it includes a substituted piperazine ring attached to a chlorinated phenyl group, and the hydrochloride form improves its solubility and stability. Through H₁ receptor blockade and mild anticholinergic action, it helps alleviate symptoms such as sneezing, itching, and nausea.
Structure of Chlorcyclizine Hydrochloride
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- Chlorcyclizine is a diphenylmethylpiperazine derivative with a chlorinated aromatic ring.
- The hydrochloride salt improves solubility.
- Chemical Formula: C₁₆H₂₈ClN₃·HCl
Mode of Action
- Acts as an H₁-receptor antagonist with additional anticholinergic and sedative properties.
- It inhibits histamine-mediated responses.
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Uses
- Allergic Reactions: Treats symptoms like sneezing, itching, and runny nose.
- Motion Sickness: Prevents and alleviates nausea and vomiting associated with travel.
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