Cyproheptadine Hydrochloride is a first-generation antihistamine known for its broad pharmacological actions, including antiserotonergic, anticholinergic, and appetite-stimulating effects. Structurally, it consists of a tricyclic dibenzocycloheptene core linked to a piperidine ring, with the hydrochloride salt improving solubility.
Structure of Cyproheptadine Hydrochloride
- Cyproheptadine features a tricyclic structure with a dibenzocycloheptene core connected to a piperidine ring.
- The hydrochloride salt enhances solubility.
- Chemical Formula: C₂₂H₂₃ClN₂·HCl
Mode of Action
- Functions as an H₁-antagonist with antiserotonergic and anticholinergic properties.
- It blocks histamine and serotonin receptors.
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Uses
- Allergic Reactions: Effective in treating symptoms like sneezing, itching, and runny nose.
- Appetite Stimulation: Used to increase appetite in conditions causing weight loss.
- Migraine Prophylaxis: Utilized in preventing migraines due to its serotonergic antagonism.
