Cyproheptadine Hydrochloride is a first-generation antihistamine known for its broad pharmacological actions, including antiserotonergic, anticholinergic, and appetite-stimulating effects. Structurally, it consists of a tricyclic dibenzocycloheptene core linked to a piperidine ring, with the hydrochloride salt improving solubility. By blocking both histamine and serotonin receptors, Cyproheptadine is effective in managing allergic conditions, promoting weight gain, and preventing migraines.
Structure of Cyproheptadine Hydrochloride
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- Cyproheptadine features a tricyclic structure with a dibenzocycloheptene core connected to a piperidine ring.
- The hydrochloride salt enhances solubility.
- Chemical Formula: C₂₂H₂₃ClN₂·HCl
Mode of Action
- Functions as an H₁-antagonist with antiserotonergic and anticholinergic properties.
- It blocks histamine and serotonin receptors.
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Uses
- Allergic Reactions: Effective in treating symptoms like sneezing, itching, and runny nose.
- Appetite Stimulation: Used to increase appetite in conditions causing weight loss.
- Migraine Prophylaxis: Utilized in preventing migraines due to its serotonergic antagonism.
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