Meclizine Hydrochloride is a piperazine-class H₁-antihistamine commonly prescribed for the prevention and treatment of motion sickness and vertigo. Its structure includes a benzyl group and diethyl substitutions, contributing to its pharmacological activity, while the hydrochloride salt improves solubility. Acting through H₁ receptor blockade and anticholinergic mechanisms, it effectively reduces nausea, dizziness, and balance-related disturbances.
Structure of Meclizine Hydrochloride
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- Meclizine is a piperazine derivative with a benzyl group and a diethyl substituent.
- The hydrochloride salt enhances solubility.
- Chemical Formula: C₂₅H₃₂N₂·HCl
Mode of Action
- Functions as an H₁-antagonist with anticholinergic effects, primarily used to prevent and treat nausea, vomiting, and dizziness caused by motion sickness.
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Uses
- Motion Sickness: Effective in preventing and treating nausea, vomiting, and dizziness.
- Vertigo: Alleviates symptoms associated with vestibular disorders.
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