Opioid Analgesics

Opioid Analgesics

Opioid Analgesics are powerful pain-relieving drugs that act on opioid receptors to reduce moderate to severe pain. Definition of Opioid Analgesics: Opioid analgesics are drugs that relieve moderate to severe pain by binding to opioid receptors in the central and peripheral nervous system. They mimic the action of endogenous opioids like endorphins and enkephalins. Opioid … Read more

Nootropics (“Smart Drugs”)

Nootropics ("Smart Drugs")

Nootropics (“Smart Drugs”) are cognitive enhancers that improve memory, focus, learning, and mental performance. Definition of Nootropics (“Smart Drugs”): Nootropics are agents that enhance cognitive functions such as memory, learning, creativity, and attention, especially in individuals with cognitive impairments. Some also show mild effects in healthy individuals. Common Nootropic Agents: Cholinesterase Inhibitors Examples: Donepezil, Rivastigmine, … Read more

CNS Stimulants

CNS Stimulants

CNS Stimulants are drugs that enhance brain activity, increasing alertness, focus, energy, and sometimes improving mood and performance. Definition of CNS Stimulants: CNS stimulants are drugs that increase activity of the central nervous system, particularly enhancing alertness, attention, wakefulness, and in some cases, motor activity. They act primarily by increasing levels of dopamine, norepinephrine, or … Read more

Drugs Used in Alzheimer’s Disease

Drugs Used in Alzheimer’s Disease

Drugs used in Alzheimer’s Disease aim to manage symptoms, slow cognitive decline, and improve daily functioning. These include cholinesterase inhibitors that enhance acetylcholine levels and NMDA receptor antagonists that regulate glutamate activity. By targeting neurotransmitter imbalances, drugs used in Alzheimer’s Disease help improve memory, thinking, and behavior, offering better quality of life for patients. Cholinesterase … Read more

Alzheimer’s Disease (AD)

Alzheimer’s Disease (AD)

Alzheimer’s Disease (AD) is a chronic neurodegenerative disorder that gradually impairs memory, thinking, and behavior. Marked by progressive cognitive decline, personality changes, and loss of independence, it is the most common cause of dementia in older adults. With no complete cure, early diagnosis, proper treatment, and supportive care play a key role in slowing progression … Read more

Mephenytoin

Chemical Structure of Mephenytoin

Mephenytoin stabilizes neuronal membranes by reducing repetitive firing through sodium channel blockade. It is an anticonvulsant used in managing generalized tonic-clonic and partial seizures. Chemical Formula: C₁₂H₁₄N₂O₂ Mechanism of Mephenytoin: Sodium channel blocker (like phenytoin) Rapid oral absorption Uses of Mephenytoin: Tonic-clonic and partial seizures (historical) Side Effects: Aplastic anemia (rare but serious) Drowsiness, ataxia … Read more

Drugs Used in Parkinson’s Disease

Drugs Used in Parkinson’s Disease

This article explains about the Drugs for Parkinson’s disease improve dopamine levels or reduce symptoms like tremors and stiffness. Dopaminergic Agents Levodopa + Carbidopa Levodopa is a precursor to dopamine that crosses the blood-brain barrier. Carbidopa inhibits peripheral DOPA decarboxylase, preventing conversion of levodopa to dopamine outside the CNS, thus increasing its bioavailability in the … Read more

Phenytoin

Phenytoin

Phenytoin controls generalized tonic-clonic and partial seizures effectively. It stabilizes neuronal membranes by blocking voltage-gated sodium channels. Chemical Formula: C₁₅H₁₂N₂O₂ Mechanism of Action: Blocks Na⁺ channels in a use-dependent manner → stabilizes hyperexcited neurons. Prevents repetitive firing. Therapeutic Uses: Tonic-clonic seizures Focal (partial) seizures Status epilepticus (IV loading) Side Effects: Gingival hyperplasia Hirsutism Ataxia, diplopia … Read more

Parkinson’s Disease (PD)

Parkinson’s Disease (PD)

Parkinson’s Disease (PD) is a progressive neurodegenerative disorder that primarily affects movement and coordination. Characterized by symptoms such as tremors, muscle stiffness, slow movements, and balance difficulties, It occurs due to a gradual loss of dopamine-producing neurons in the brain. Early diagnosis and proper management with medications, lifestyle changes, and therapies can help improve quality of … Read more

Metharbital

Metharbital

Metharbital, a barbiturate, enhances GABA activity, producing anticonvulsant and sedative effects. It is prescribed for epilepsy, offering control over generalized and partial seizures. Chemical Formula: C₉H₁₄N₂O₃ Mechanism of Action: Similar to phenobarbital; enhances GABAergic inhibition Therapeutic Uses of Metharbital: Formerly used for generalized tonic-clonic seizures Less potent, more sedating than phenobarbital Side Effects of Metharbital: … Read more